Sequence of PIGK_MONRU
EC Number:2.3.1.86
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+
General information:
Sequence
0 MEASDQSQAK LTLSFGGIQH AFSVPIEDLS ALQDQKDAFL RSRSQASLSE TREPCSPAEL
60 MLDYLEFLSC RNLPPPLTKP VLLAFSRNFL HNTEIHSLLA KPEYTPQTRR RLVRTYYMAA
120 LSAAESHVKE SALLDAARQG NFQLAAVFGG QSTANPACVR ELAELFAAYT PFLGDLISTA
180 APTLSALCRL PETKEHFCGR HIDIETWLHD PASIPDGDFI ATAPVSCPVV GLLNLAHYAV
240 TCHVLGKTPG ELRSHLQGVT GHSQGIVAAV AISLSDSWES FYEAARMTVE TLFWIGFECH
300 QRSPRTSVSL DQVQDSLQNG HGRPSCMLSI VGLSRAHIQD ILLKLNRSLP EDEQVYLALD
360 NARDSFVVAG PSCSLVHLHT YLRSLKADAS IDQTRIPHSL RKPTVQHQFL PISVPFHTPY
420 LQEAARAIKE RLFPWRVVSG KLTIPVYDNR TGNDLRKSDN VNLIHTMVDS ICWEPCSWPA
480 ALGIENISHI VAFGSGGVGE LAMRLKDGQG VRVIIGSEFQ SRDEEIGTKA DLFSPTLLAS
540 STIVGSWGER FRPRLSKSPT GEVKIETKLS RLLDTPPLMV AGMTPTTAAW DFVSAITNAG
600 YHVELAGGGY YDMDAMAVAV KKLVASIPPG RGITCNVIYA SPQTLSGQVT LLRRLSSQGL
660 PIDGLTIGAG IPSLEVVSEY IQALGLRHIS LKPGSITAIR EVIEIAKAHP DFPIILQWTG
720 GRGGGHHSFE DFHAPILRTY GALRRCSNII LVAGSGFGGS EDTYPYLSGT WSAQYGLPAM
780 PFDGILLGSR IMVAKEAHTS PAAKRLITEA SGVSDSDWEK TYQEATGGVI TVVSEMGQPI
840 HKIATRGVLF WAEMDKTIFS LPRTKRVPEL LKRRDYIIKR LNADFAKPWF GQNSKGEPVD
900 LSEMTYIEVL RRLVALMYVS HQSRWIDPSY MTLLMDVSVR ILERFSIVDE LDDALVLREP
960 HRFVENIVRL CPPAAHDILS PEDVAWFLLR CKARGQKPVN FIPALDDDFE TFFKKDSLWQ
1020 SEDVDALIDQ DAGRCCILHG PVAAQYSQDR DEPAKEILDG ITQSWIDMIR HDFYPGGVTP
1080 SSDSGSLSSE SWSVLTPDLT SRDESALLDI IPEMQAYCPS ISSLGRSGSP WIHALLSDEF
1140 ILQGRDRRPN PCRRVFHFGP GGSLQFDRAK SEITVSMENH AGNRSVMRIV CENGADISVD
1200 LQQPSAYTDE MVSLPLKFQY DPGMVPVGIS EVMEGRNERI KSFYSKVWFG EDICRGMNAR
1260 SVFHGSEMAL TEAMHRDLLS TVSLAYPHSE TALSGVDVFP ISVGMFPVWD AMARPLVVND
1320 IDGDLLRLVH ESNTFEYCEA STPLRVGDVV SSTAAVRAVY IEDAGKHVVV EASIERSGKP
1380 VMKVVSTFLF KGVFNDWNST FKTNKEPELV LDVQSDLDEL VLRDREWLLL HDPSQSLVGC
1440 SLLFRLETQV TWKNRNTYRS LDVSGLVFLQ QASDDLKEIG AVAFHAGECV GNPVLSFLQR
1500 KGSPATSPTP LTSPGWPGVS SLEVQLPTSN EMYTRTSRDY NPIHVSPLFS QWADLPGTIT
1560 QGMYTSAISA AVLEHLALNG DRRRFRRFSA RFTDMVLPGD RLLVNVKHVG SIQGRMLFNV
1620 SAFKQATNNM VLEAEAELEQ PPTAFFFTGQ GSQKPNMGMD LYNSSPVAKA IWDEADKYIF
1680 ETYGWSILDI VKNNPKTLTI HFRGKHGRKI RANYLSMENK TVTPDGQIVK KPILPGLTDQ
1740 TQSYTFTEPS GLLFFSTFAQ PSIVVMEKAT FEDMRSKGLI PQSAVFAGHS LGEYGALLAF
1800 SGFMSVRNLV DLVFYRGLSM QFAMERDERG ETNFGMVAAS PQRVGKSDAV FTESHLRSLV
1860 QMISIASHEL LEMVNLNIEN EQYVCAGTDT ETQLLLEEMS TTEDRTTTKL YKLILKSIPA
1920 TKKLPMPIRL QRGRCTIPIP GIDVPFHSSY LRSTVSSYRK ILQQYISEED VHLERLVGRW
1980 IPNVTAKPFM ADEGYVREVF NITQSPILKE MLEL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
6969
Wong H.C.,Bau Y.S.
Pigmentation and antibacterial activity of fast neutron- and X-ray-induced strains of Monascus purpureus went.
Plant Physiol.
60
578-581
1977
6970
Akihisa T.,Tokuda H.,Ukiya M.,Kiyota A.,Yasukawa K.,Sakamoto N.,Kimura Y.,Suzuki T.,Takayasu J.,Nishino H.
Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).
Chem. Biodivers.
2
1305-1309
2005
6971
Lee C.L.,Tsai T.Y.,Wang J.J.,Pan T.M.
In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia.
Appl. Microbiol. Biotechnol.
70
533-540
2006
6972
Lee C.L.,Kung Y.H.,Wu C.L.,Hsu Y.W.,Pan T.M.
Monascin and ankaflavin act as novel hypolipidemic and high-density lipoprotein cholesterol-raising agents in red mold dioscorea.
J. Agric. Food Chem.
58
9013-9019
2010
6973
Lee C.L.,Pan T.M.
Development of Monascus fermentation technology for high hypolipidemic effect.
Appl. Microbiol. Biotechnol.
94
1449-1459
2012
6974
Liu J.,Zhou Y.,Yi T.,Zhao M.,Xie N.,Lei M.,Liu Q.,Shao Y.,Chen F.
Identification and role analysis of an intermediate produced by a polygenic mutant of Monascus pigments cluster in Monascus ruber M7.
Appl. Microbiol. Biotechnol.
100
7037-7049
2016
6975
Chen W.,Chen R.,Liu Q.,He Y.,He K.,Ding X.,Kang L.,Guo X.,Xie N.,Zhou Y.,Lu Y.,Cox R.J.,Molnar I.,Li M.,Shao Y.,Chen F.
Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi.
Chem. Sci.
8
4917-4925
2017
6976
Liu Q.,Zhong S.,Wang X.,Gao S.,Yang X.,Chen F.,Molnar I.
An integrated approach to determine the boundaries of the azaphilone pigment biosynthetic gene cluster of Monascus ruber M7 gown on potato dextrose agar.
Front. Microbiol.
12
680629-680629
2021
6977
Ree Yoon H.,Han S.,Chul Shin S.,Cheong Yeom S.,Jin Kim H.
Improved natural food colorant production in the filamentous fungus Monascus ruber using CRISPR-based engineering.
Food Res. Intern.
167
112651-112651
2023
