Sequence of AK1C1_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
indanol dehydrogenase
Q04828
Homo sapiens
323
36788
Reaction
indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ
 60 VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV
120 SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP
180 GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV
240 LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN
300 RNVRYLTLDI FAGPPNYPFS DEY
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
251329
Stolz A.,Hammond L.,Lou H.,Takikawa H.,Ronk M.,Shively J.E.
cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.
J. Biol. Chem.
268
10448-10457
1993
251330
Lou H.,Hammond L.,Sharma V.,Sparkes R.S.,Lusis A.J.,Stolz A.
Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding.
J. Biol. Chem.
269
8416-8422
1994
251331
Ciaccio P.J.,Jaiswal A.K.,Tew K.D.
Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
J. Biol. Chem.
269
15558-15562
1994
251332
Khanna M.,Qin K.-N.,Cheng K.-C.
Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.
J. Steroid Biochem. Mol. Biol.
53
41-46
1995
251333
Nishizawa M.,Nakajima T.,Yasuda K.,Kanzaki H.,Sasaguri Y.,Watanabe K.,Ito S.
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.
Genes Cells
5
111-125
2000
251334
Zhang Y.,Dufort I.,Rheault P.,Luu-The V.
Characterization of a human 20alpha-hydroxysteroid dehydrogenase.
J. Mol. Endocrinol.
25
221-228
2000
251336
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
251337
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
251338
Qin K.-N.,New M.I.,Cheng K.-C.
Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
J. Steroid Biochem. Mol. Biol.
46
673-679
1993
251339
Hara A.,Matsuura K.,Tamada Y.,Sato K.,Miyabe Y.,Deyashiki Y.,Ishida N.
Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.
Biochem. J.
313
373-376
1996
251340
Deyashiki Y.,Ogasawara A.,Nakayama T.,Nakanishi M.,Miyabe Y.,Sato K.,Hara A.
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
Biochem. J.
299
545-552
1994
251341
Couture J.-F.,Legrand P.,Cantin L.,Luu-The V.,Labrie F.,Breton R.
Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.
J. Mol. Biol.
331
593-604
2003
251342
El-Kabbani O.,Dhagat U.,Soda M.,Endo S.,Matsunaga T.,Hara A.
Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.
Bioorg. Med. Chem. Lett.
21
2564-2567
2011