Sequence of CP2C9_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
unspecific monooxygenase
P11712
Homo sapiens
490
55628
Reaction
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MDSLVVLVLC LSCLLLLSLW RQSSGRGKLP PGPTPLPVIG NILQIGIKDI SKSLTNLSKV
 60 YGPVFTLYFG LKPIVVLHGY EAVKEALIDL GEEFSGRGIF PLAERANRGF GIVFSNGKKW
120 KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTK ASPCDPTFIL GCAPCNVICS
180 IIFHKRFDYK DQQFLNLMEK LNENIKILSS PWIQICNNFS PIIDYFPGTH NKLLKNVAFM
240 KSYILEKVKE HQESMDMNNP QDFIDCFLMK MEKEKHNQPS EFTIESLENT AVDLFGAGTE
300 TTSTTLRYAL LLLLKHPEVT AKVQEEIERV IGRNRSPCMQ DRSHMPYTDA VVHEVQRYID
360 LLPTSLPHAV TCDIKFRNYL IPKGTTILIS LTSVLHDNKE FPNPEMFDPH HFLDEGGNFK
420 KSKYFMPFSA GKRICVGEAL AGMELFLFLT SILQNFNLKS LVDPKNLDTT PVVNGFASVP
480 PFYQLCFIPV
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18629
Meehan R.R.,Gosden J.R.,Rout D.,Hastie N.D.,Friedberg T.,Adesnik M.,Buckland R.,van Heyningen V.,Fletcher J.M.,Spurr N.K.,Sweeney J.,Wolf C.R.
Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.
Am. J. Hum. Genet.
42
26-37
1988
18630
Kimura S.,Pastewka J.,Gelboin H.V.,Gonzalez F.J.
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.
Nucleic Acids Res.
15
10053-10054
1987
18632
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
18633
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
18635
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
18636
Yasumori T.,Kawano S.,Nagata K.,Shimada M.,Yamazoe Y.,Kato R.
Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form.
J. Biochem.
102
1075-1082
1987
18637
Umbenhauer D.R.,Martin M.V.,Lloyd R.S.,Guengerich F.P.
Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase.
Biochemistry
26
1094-1099
1987
18638
Ged C.,Umbenhauer D.R.,Bellew T.M.,Bork R.W.,Srivastava P.K.,Shinriki N.,Lloyd R.S.,Guengerich F.P.
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
Biochemistry
27
6929-6940
1988
18639
Ohgiya S.,Komori M.,Ohi H.,Shiramatsu K.,Shinriki N.,Kamataki T.
Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity.
Biochem. Int.
27
1073-1081
1992
18640
Shimada T.,Misono K.S.,Guengerich F.P.
Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.
J. Biol. Chem.
261
909-921
1986
18641
Komori M.,Hashizume T.,Ohi H.,Miura T.,Kitada M.,Nagashima K.,Kamataki T.
Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.
J. Biochem.
104
912-916
1988
18642
Srivastava P.K.,Yun C.H.,Beaune P.H.,Ged C.,Guengerich F.P.
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
Mol. Pharmacol.
40
69-79
1991
18643
Haining R.L.,Hunter A.P.,Veronese M.E.,Trager W.F.,Rettie A.E.
Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.
Arch. Biochem. Biophys.
333
447-458
1996
18644
Sandhu P.,Baba T.,Guengerich F.P.
Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity.
Arch. Biochem. Biophys.
306
443-450
1993
18645
Zeldin D.C.,DuBois R.N.,Falck J.R.,Capdevila J.H.
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Arch. Biochem. Biophys.
322
76-86
1995
18646
Bylund J.,Ericsson J.,Oliw E.H.
Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.
Anal. Biochem.
265
55-68
1998
18647
Bylund J.,Kunz T.,Valmsen K.,Oliw E.H.
Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.
J. Pharmacol. Exp. Ther.
284
51-60
1998
18648
Miyazawa M.,Shindo M.,Shimada T.
Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.
Drug Metab. Dispos.
30
602-607
2002
18649
Lee A.J.,Cai M.X.,Thomas P.E.,Conney A.H.,Zhu B.T.
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
Endocrinology
144
3382-3398
2003
18650
Barbosa-Sicard E.,Markovic M.,Honeck H.,Christ B.,Muller D.N.,Schunck W.H.
Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.
Biochem. Biophys. Res. Commun.
329
1275-1281
2005
18651
Lucas D.,Goulitquer S.,Marienhagen J.,Fer M.,Dreano Y.,Schwaneberg U.,Amet Y.,Corcos L.
Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.
J. Lipid Res.
51
1125-1133
2010
18652
Honda A.,Miyazaki T.,Ikegami T.,Iwamoto J.,Maeda T.,Hirayama T.,Saito Y.,Teramoto T.,Matsuzaki Y.
Cholesterol 25-hydroxylation activity of CYP3A.
J. Lipid Res.
52
1509-1516
2011
18653
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
18654
Williams P.A.,Cosme J.,Ward A.,Angove H.C.,Matak-Vinkovic D.,Jhoti H.
Crystal structure of human cytochrome P450 2C9 with bound warfarin.
Nature
424
464-468
2003
18655
Stubbins M.J.,Harries L.W.,Smith G.,Tarbit M.H.,Wolf C.R.
Genetic analysis of the human cytochrome P450 CYP2C9 locus.
Pharmacogenetics
6
429-439
1996
18656
Bhasker C.R.,Miners J.O.,Coulter S.,Birkett D.J.
Allelic and functional variability of cytochrome P4502C9.
Pharmacogenetics
7
51-58
1997
18657
Imai J.,Ieiri I.,Mamiya K.,Miyahara S.,Furuumi H.,Nanba E.,Yamane M.,Fukumaki Y.,Ninomiya H.,Tashiro N.,Otsubo K.,Higuchi S.
Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus.
Pharmacogenetics
10
85-89
2000
18658
Dickmann L.J.,Rettie A.E.,Kneller M.B.,Kim R.B.,Wood A.J.,Stein C.M.,Wilkinson G.R.,Schwarz U.I.
Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans.
Mol. Pharmacol.
60
382-387
2001
18659
Higashi M.K.,Veenstra D.L.,Kondo L.M.,Wittkowsky A.K.,Srinouanprachanh S.L.,Farin F.M.,Rettie A.E.
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy.
JAMA
287
1690-1698
2002
18660
Solus J.F.,Arietta B.J.,Harris J.R.,Sexton D.P.,Steward J.Q.,McMunn C.,Ihrie P.,Mehall J.M.,Edwards T.L.,Dawson E.P.
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Pharmacogenomics
5
895-931
2004
18661
Ciccacci C.,Falconi M.,Paolillo N.,Oteri F.,Forte V.,Novelli G.,Desideri A.,Borgiani P.
Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient.
Pharmacogenet. Genomics
21
344-346
2011
18662
Nahar R.,Dube D.,Parakh R.,Deb R.,Saxena R.,Singh T.P.,Verma I.C.
Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity.
Thromb. Res.
131
535-539
2013
18663
Lee Y.M.,Eggen J.,Soni V.,Drozda K.,Nutescu E.A.,Cavallari L.H.
Warfarin dose requirements in a patient with the CYP2C9*14 allele.
Pharmacogenomics
15
909-914
2014
18664
Dai D.P.,Wang S.H.,Li C.B.,Geng P.W.,Cai J.,Wang H.,Hu G.X.,Cai J.P.
Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59.
Drug Metab. Dispos.
43
1246-1249
2015