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Sequence of HEPS_HUMAN

EC Number:3.4.21.106

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hepsin
P05981
Homo sapiens
417
45011
Reaction
cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Other sequences found for EC No. 3.4.21.106

General information:

Sequence
show sequence in fasta format
  0 MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD
 60 ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV
120 DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL
180 RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH
240 GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ
300 YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE
360 DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
171445
Leytus S.P.,Loeb K.R.,Hagen F.S.,Kurachi K.,Davie E.W.
A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.
Biochemistry
27
1067-1074
1988
171446
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
171447
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
171448
Tsuji A.,Torres-Rosado A.,Arai T.,le Beau M.M.,Lemons R.S.,Chou S.H.,Kurachi K.
Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.
J. Biol. Chem.
266
16948-16953
1991
171449
Torres-Rosado A.,O'Shea K.S.,Tsuji A.,Chou S.-H.,Kurachi K.
Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.
Proc. Natl. Acad. Sci. U.S.A.
90
7181-7185
1993
171450
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
171451
Ganesan R.,Kolumam G.A.,Lin S.J.,Xie M.H.,Santell L.,Wu T.D.,Lazarus R.A.,Chaudhuri A.,Kirchhofer D.
Proteolytic activation of pro-macrophage-stimulating protein by hepsin.
Mol. Cancer Res.
9
1175-1186
2011
171452
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
171453
Heurich A.,Hofmann-Winkler H.,Gierer S.,Liepold T.,Jahn O.,Poehlmann S.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
J. Virol.
88
1293-1307
2014
171454
Brunati M.,Perucca S.,Han L.,Cattaneo A.,Consolato F.,Andolfo A.,Schaeffer C.,Olinger E.,Peng J.,Santambrogio S.,Perrier R.,Li S.,Bokhove M.,Bachi A.,Hummler E.,Devuyst O.,Wu Q.,Jovine L.,Rampoldi L.
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.
Elife
4
0-0
2015
171455
Somoza J.R.,Ho J.D.,Luong C.,Ghate M.,Sprengeler P.A.,Mortara K.,Shrader W.D.,Sperandio D.,Chan H.,McGrath M.E.,Katz B.A.
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
Structure
11
1123-1131
2003
171456
Herter S.,Piper D.E.,Aaron W.,Gabriele T.,Cutler G.,Cao P.,Bhatt A.S.,Choe Y.,Craik C.S.,Walker N.,Meininger D.,Hoey T.,Austin R.J.
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
Biochem. J.
390
125-136
2005