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Sequence of GPX4_HUMAN

EC Number:1.11.1.12

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phospholipid-hydroperoxide glutathione peroxidase
P36969
Homo sapiens
197
22175
Reaction
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
Other sequences found for EC No. 1.11.1.12

General information:

Sequence
show sequence in fasta format
  0 MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR
 60 GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA
120 AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY
180 GPMEEPLVIE KDLPHYF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
168506
Esworthy R.S.,Doan K.,Doroshow J.H.,Chu F.-F.
Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.
Gene
144
317-318
1994
168507
Kelner M.J.,Montoya M.A.
Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.
Biochem. Biophys. Res. Commun.
249
53-55
1998
168509
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
168510
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
168511
Sutherland M.,Shankaranarayanan P.,Schewe T.,Nigam S.
Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.
Biochem. J.
353
91-100
2001
168512
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
168513
Yang W.S.,SriRamaratnam R.,Welsch M.E.,Shimada K.,Skouta R.,Viswanathan V.S.,Cheah J.H.,Clemons P.A.,Shamji A.F.,Clish C.B.,Brown L.M.,Girotti A.W.,Cornish V.W.,Schreiber S.L.,Stockwell B.R.
Regulation of ferroptotic cancer cell death by GPX4.
Cell
156
317-331
2014
168514
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
168515
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
168516
Scheerer P.,Borchert A.,Krauss N.,Wessner H.,Gerth C.,Hoehne W.,Kuhn H.
Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4).
Biochemistry
46
9041-9049
2007
168518
Sakamoto K.,Sogabe S.,Kamada Y.,Matsumoto S.I.,Kadotani A.,Sakamoto J.I.,Tani A.
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.
Biochem. Biophys. Res. Commun.
482
195-201
2017
168519
Maiorino M.,Bosello V.,Ursini F.,Foresta C.,Garolla A.,Scapin M.,Sztajer H.,Flohe L.
Genetic variations of gpx-4 and male infertility in humans.
Biol. Reprod.
68
1134-1141
2003
168520
Smith A.C.,Mears A.J.,Bunker R.,Ahmed A.,MacKenzie M.,Schwartzentruber J.A.,Beaulieu C.L.,Ferretti E.,Majewski J.,Bulman D.E.,Celik F.C.,Boycott K.M.,Graham G.E.
Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia.
J. Med. Genet.
51
470-474
2014