Sequence of CS12A_FRATN
EC Number:3.1.21.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
General information:
Sequence
0 MSIYQEFVNK YSLSKTLRFE LIPQGKTLEN IKARGLILDD EKRAKDYKKA KQIIDKYHQF
60 FIEEILSSVC ISEDLLQNYS DVYFKLKKSD DDNLQKDFKS AKDTIKKQIS EYIKDSEKFK
120 NLFNQNLIDA KKGQESDLIL WLKQSKDNGI ELFKANSDIT DIDEALEIIK SFKGWTTYFK
180 GFHENRKNVY SSNDIPTSII YRIVDDNLPK FLENKAKYES LKDKAPEAIN YEQIKKDLAE
240 ELTFDIDYKT SEVNQRVFSL DEVFEIANFN NYLNQSGITK FNTIIGGKFV NGENTKRKGI
300 NEYINLYSQQ INDKTLKKYK MSVLFKQILS DTESKSFVID KLEDDSDVVT TMQSFYEQIA
360 AFKTVEEKSI KETLSLLFDD LKAQKLDLSK IYFKNDKSLT DLSQQVFDDY SVIGTAVLEY
420 ITQQIAPKNL DNPSKKEQEL IAKKTEKAKY LSLETIKLAL EEFNKHRDID KQCRFEEILA
480 NFAAIPMIFD EIAQNKDNLA QISIKYQNQG KKDLLQASAE DDVKAIKDLL DQTNNLLHKL
540 KIFHISQSED KANILDKDEH FYLVFEECYF ELANIVPLYN KIRNYITQKP YSDEKFKLNF
600 ENSTLANGWD KNKEPDNTAI LFIKDDKYYL GVMNKKNNKI FDDKAIKENK GEGYKKIVYK
660 LLPGANKMLP KVFFSAKSIK FYNPSEDILR IRNHSTHTKN GSPQKGYEKF EFNIEDCRKF
720 IDFYKQSISK HPEWKDFGFR FSDTQRYNSI DEFYREVENQ GYKLTFENIS ESYIDSVVNQ
780 GKLYLFQIYN KDFSAYSKGR PNLHTLYWKA LFDERNLQDV VYKLNGEAEL FYRKQSIPKK
840 ITHPAKEAIA NKNKDNPKKE SVFEYDLIKD KRFTEDKFFF HCPITINFKS SGANKFNDEI
900 NLLLKEKAND VHILSIDRGE RHLAYYTLVD GKGNIIKQDT FNIIGNDRMK TNYHDKLAAI
960 EKDRDSARKD WKKINNIKEM KEGYLSQVVH EIAKLVIEYN AIVVFEDLNF GFKRGRFKVE
1020 KQVYQKLEKM LIEKLNYLVF KDNEFDKTGG VLRAYQLTAP FETFKKMGKQ TGIIYYVPAG
1080 FTSKICPVTG FVNQLYPKYE SVSKSQEFFS KFDKICYNLD KGYFEFSFDY KNFGDKAAKG
1140 KWTIASFGSR LINFRNSDKN HNWDTREVYP TKELEKLLKD YSIEYGHGEC IKAAICGESD
1200 KKFFAKLTSV LNTILQMRNS KTGTELDYLI SPVADVNGNF FDSRQAPKNM PQDADANGAY
1260 HIGLKGLMLL GRIKNNQEGK KLNLVIKNEE YFEFVQNRNN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18937
Rohmer L.,Fong C.,Abmayr S.,Wasnick M.,Larson Freeman T.J.,Radey M.,Guina T.,Svensson K.,Hayden H.S.,Jacobs M.,Gallagher L.A.,Manoil C.,Ernst R.K.,Drees B.,Buckley D.,Haugen E.,Bovee D.,Zhou Y.,Chang J.,Levy R.,Lim R.,Gillett W.,Guenthener D.,Kang A.,Shaffer S.A.,Taylor G.,Chen J.,Gallis B.,D'Argenio D.A.,Forsman M.,Olson M.V.,Goodlett D.R.,Kaul R.,Miller S.I.,Brittnacher M.J.
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains.
Genome Biol.
8
R102.1-R102.16
2007
18938
Zetsche B.,Gootenberg J.S.,Abudayyeh O.O.,Slaymaker I.M.,Makarova K.S.,Essletzbichler P.,Volz S.E.,Joung J.,van der Oost J.,Regev A.,Koonin E.V.,Zhang F.
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
Cell
163
759-771
2015
18939
Shmakov S.,Abudayyeh O.O.,Makarova K.S.,Wolf Y.I.,Gootenberg J.S.,Semenova E.,Minakhin L.,Joung J.,Konermann S.,Severinov K.,Zhang F.,Koonin E.V.
Discovery and functional characterization of diverse class 2 CRISPR-Cas systems.
Mol. Cell
60
385-397
2015
18940
Fonfara I.,Richter H.,Bratovic M.,Le Rhun A.,Charpentier E.
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.
Nature
532
517-521
2016
18941
Endo A.,Masafumi M.,Kaya H.,Toki S.
Efficient targeted mutagenesis of rice and tobacco genomes using Cpf1 from Francisella novicida.
Sci. Rep.
6
38169-38169
2016
18942
Kim D.,Kim J.,Hur J.K.,Been K.W.,Yoon S.H.,Kim J.S.
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells.
Nat. Biotechnol.
34
863-868
2016
18943
Shmakov S.,Smargon A.,Scott D.,Cox D.,Pyzocha N.,Yan W.,Abudayyeh O.O.,Gootenberg J.S.,Makarova K.S.,Wolf Y.I.,Severinov K.,Zhang F.,Koonin E.V.
Diversity and evolution of class 2 CRISPR-Cas systems.
Nat. Rev. Microbiol.
15
169-182
2017
18944
Tao J.,Bauer D.E.,Chiarle R.
Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing.
Nat. Commun.
14
212-212
2023
18945
Swarts D.C.,van der Oost J.,Jinek M.
Structural basis for guide RNA processing and seed-dependent DNA targeting by CRISPR-Cas12a.
Mol. Cell
66
221-233
2017
18946
Stella S.,Alcon P.,Montoya G.
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.
Nature
546
559-563
2017
18947
Stella S.,Alcon P.,Montoya G.
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.
Nature
547
476-476
2017
