Sequence of ABL1_HUMAN
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE
60 NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN
120 SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS
180 DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTVYGVSP NYDKWEMERT
240 DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ
300 LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVNAVVL LYMATQISSA MEYLEKKNFI
360 HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS
420 DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP
480 SDRPSFAEIH QAFETMFQES SISDEVEKEL GKQGVRGAVS TLLQAPELPT KTRTSRRAAE
540 HRDTTDVPEM PHSKGQGESD PLDHEPAVSP LLPRKERGPP EGGLNEDERL LPKDKKTNLF
600 SALIKKKKKT APTPPKRSSS FREMDGQPER RGAGEEEGRD ISNGALAFTP LDTADPAKSP
660 KPSNGAGVPN GALRESGGSG FRSPHLWKKS STLTSSRLAT GEEEGGGSSS KRFLRSCSAS
720 CVPHGAKDTE WRSVTLPRDL QSTGRQFDSS TFGGHKSEKP ALPRKRAGEN RSDQVTRGTV
780 TPPPRLVKKN EEAADEVFKD IMESSPGSSP PNLTPKPLRR QVTVAPASGL PHKEEAGKGS
840 ALGTPAAAEP VTPTSKAGSG APGGTSKGPA EESRVRRHKH SSESPGRDKG KLSRLKPAPP
900 PPPAASAGKA GGKPSQSPSQ EAAGEAVLGA KTKATSLVDA VNSDAAKPSQ PGEGLKKPVL
960 PATPKPQSAK PSGTPISPAP VPSTLPSASS ALAGDQPSST AFIPLISTRV SLRKTRQPPE
1020 RIASGAITKG VVLDSTEALC LAISRNSEQM ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK
1080 FAFREAINKL ENNLRELQIC PATAGSGPAA TQDFSKLLSS VKEISDIVQR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
127812
Shtivelman E.,Lifshitz B.,Gale R.P.,Roe B.A.,Canaani E.
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
Cell
47
277-284
1986
127813
Fainstein E.,Einat M.,Gokkel E.,Marcelle C.,Croce C.M.,Gale R.P.,Canaani E.
Nucleotide sequence analysis of human abl and bcr-abl cDNAs.
Oncogene
4
1477-1481
1989
127814
Chissoe S.L.,Bodenteich A.,Wang Y.-F.,Wang Y.-P.,Burian D.,Clifton S.W.,Crabtree J.,Freeman A.,Iyer K.,Jian L.,Ma Y.,McLaury H.-J.,Pan H.-Q.,Sarhan O.H.,Toth S.,Wang Z.,Zhang G.,Heisterkamp N.,Groffen J.,Roe B.A.
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
Genomics
27
67-82
1995
127816
Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.
DNA sequence and analysis of human chromosome 9.
Nature
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369-374
2004
127818
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
127819
Fainstein E.,Marcelle C.,Rosner A.,Canaani E.,Gale R.P.,Dreazen O.,Smith S.D.,Croce C.M.
A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.
Nature
330
386-388
1987
127820
Groffen J.,Heisterkamp N.,Reynolds F.H. Jr.,Stephenson J.R.
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
Nature
304
167-169
1983
127821
Inokuchi K.,Futaki M.,Dan K.,Nomura T.
Sequence analysis of the mutation at codon 834 and the sequence variation of codon 837 of c-abl gene.
Leukemia
8
343-344
1994
127822
Jackson P.,Baltimore D.
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
EMBO J.
8
449-456
1989
127823
Kipreos E.T.,Wang J.Y.
Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
Science
248
217-220
1990
127824
Yuan Z.M.,Huang Y.,Ishiko T.,Kharbanda S.,Weichselbaum R.,Kufe D.
Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
Proc. Natl. Acad. Sci. U.S.A.
94
1437-1440
1997
127825
Han L.,Wong D.,Dhaka A.,Afar D.E.H.,White M.,Xie W.,Herschman H.,Witte O.,Colicelli J.
Protein binding and signaling properties of RIN1 suggest a unique effector function.
Proc. Natl. Acad. Sci. U.S.A.
94
4954-4959
1997
127826
Yuan Z.M.,Huang Y.,Ishiko T.,Nakada S.,Utsugisawa T.,Kharbanda S.,Wang R.,Sung P.,Shinohara A.,Weichselbaum R.,Kufe D.
Regulation of Rad51 function by c-Abl in response to DNA damage.
J. Biol. Chem.
273
3799-3802
1998
127827
Wisniewski D.,Strife A.,Swendeman S.,Erdjument-Bromage H.,Geromanos S.,Kavanaugh W.M.,Tempst P.,Clarkson B.
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
Blood
93
2707-2720
1999
127828
Agami R.,Blandino G.,Oren M.,Shaul Y.
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.
Nature
399
809-813
1999
127829
David-Cordonnier M.H.,Payet D.,D'Halluin J.C.,Waring M.J.,Travers A.A.,Bailly C.
The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA.
Nucleic Acids Res.
27
2265-2270
1999
127831
Lin W.-H.,Huang C.-J.,Liu M.-W.,Chang H.-M.,Chen Y.-J.,Tai T.-Y.,Chuang L.-M.
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
Genomics
74
12-20
2001
127832
Kitao H.,Yuan Z.M.
Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.
J. Biol. Chem.
277
48944-48948
2002
127833
Yoshida K.,Komatsu K.,Wang H.-G.,Kufe D.
c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Mol. Cell. Biol.
22
3292-3300
2002
127834
Soubeyran P.,Barac A.,Szymkiewicz I.,Dikic I.
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Biochem. J.
370
29-34
2003
127835
Sanguinetti A.R.,Mastick C.C.
c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.
Cell. Signal.
15
289-298
2003
127836
Tani K.,Sato S.,Sukezane T.,Kojima H.,Hirose H.,Hanafusa H.,Shishido T.
Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
J. Biol. Chem.
278
21685-21692
2003
127837
Woodring P.J.,Hunter T.,Wang J.Y.
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
J. Cell Sci.
116
2613-2626
2003
127838
Laurent C.E.,Smithgall T.E.
The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Exp. Cell Res.
299
188-198
2004
127839
Grossmann A.H.,Kolibaba K.S.,Willis S.G.,Corbin A.S.,Langdon W.S.,Deininger M.W.,Druker B.J.
Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
FEBS Lett.
577
555-562
2004
127840
Perkinton M.S.,Standen C.L.,Lau K.F.,Kesavapany S.,Byers H.L.,Ward M.,McLoughlin D.M.,Miller C.C.
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
J. Biol. Chem.
279
22084-22091
2004
127841
Shaul Y.,Ben-Yehoyada M.
Role of c-Abl in the DNA damage stress response.
Cell Res.
15
33-35
2005
127842
Hu H.,Bliss J.M.,Wang Y.,Colicelli J.
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
Curr. Biol.
15
815-823
2005
127843
Raina D.,Pandey P.,Ahmad R.,Bharti A.,Ren J.,Kharbanda S.,Weichselbaum R.,Kufe D.
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
J. Biol. Chem.
280
11147-11151
2005
127844
Yoshida K.,Yamaguchi T.,Natsume T.,Kufe D.,Miki Y.
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
Nat. Cell Biol.
7
278-285
2005
127845
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
127846
di Bari M.G.,Ciuffini L.,Mingardi M.,Testi R.,Soddu S.,Barila D.
c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.
EMBO Rep.
7
727-733
2006
127847
Meyn M.A. III,Wilson M.B.,Abdi F.A.,Fahey N.,Schiavone A.P.,Wu J.,Hochrein J.M.,Engen J.R.,Smithgall T.E.
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
J. Biol. Chem.
281
30907-30916
2006
127848
Tanos B.,Pendergast A.M.
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
J. Biol. Chem.
281
32714-32723
2006
127849
Liu X.,Huang W.,Li C.,Li P.,Yuan J.,Li X.,Qiu X.B.,Ma Q.,Cao C.
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
Mol. Cell
22
317-327
2006
127850
Boyle S.N.,Michaud G.A.,Schweitzer B.,Predki P.F.,Koleske A.J.
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
Curr. Biol.
17
445-451
2007
127851
Sossey-Alaoui K.,Li X.,Cowell J.K.
c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
J. Biol. Chem.
282
26257-26265
2007
127852
Jung J.H.,Pendergast A.M.,Zipfel P.A.,Traugh J.A.
Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
Biochemistry
47
1094-1104
2008
127853
Xiong X.,Cui P.,Hossain S.,Xu R.,Warner B.,Guo X.,An X.,Debnath A.K.,Cowburn D.,Kotula L.
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.
Biochim. Biophys. Acta
1783
737-747
2008
127854
Yogalingam G.,Pendergast A.M.
Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
J. Biol. Chem.
283
35941-35953
2008
127855
Chen S.,O'Reilly L.P.,Smithgall T.E.,Engen J.R.
Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
J. Mol. Biol.
383
414-423
2008
127856
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
127857
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
127858
Backert S.,Feller S.M.,Wessler S.
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Trends Biochem. Sci.
33
80-90
2008
127859
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
127860
Fernow I.,Tomasovic A.,Siehoff-Icking A.,Tikkanen R.
Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases.
BMC Cell Biol.
10
80-80
2009
127861
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
127862
Vepachedu R.,Karim Z.,Patel O.,Goplen N.,Alam R.
Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
PLoS ONE
4
0-0
2009
127863
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
127864
Michael M.,Vehlow A.,Navarro C.,Krause M.
c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.
Curr. Biol.
20
783-791
2010
127865
Dudek S.M.,Chiang E.T.,Camp S.M.,Guo Y.,Zhao J.,Brown M.E.,Singleton P.A.,Wang L.,Desai A.,Arce F.T.,Lal R.,Van Eyk J.E.,Imam S.Z.,Garcia J.G.N.
Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.
Mol. Biol. Cell
21
4042-4056
2010
127866
Colicelli J.
ABL tyrosine kinases: evolution of function, regulation, and specificity.
Sci. Signal.
3
0-0
2010
127867
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
127868
Muppirala M.,Gupta V.,Swarup G.
Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.
Biochim. Biophys. Acta
1823
2109-2119
2012
127869
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
127870
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
127871
Cobbaut M.,Derua R.,Doeppler H.,Lou H.J.,Vandoninck S.,Storz P.,Turk B.E.,Seufferlein T.,Waelkens E.,Janssens V.,Van Lint J.
Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
Sci. Rep.
7
887-887
2017
127872
Overduin M.,Rios C.B.,Mayer B.J.,Baltimore D.,Cowburn D.
Three-dimensional solution structure of the src homology 2 domain of c-abl.
Cell
70
697-704
1992
127873
Overduin M.,Mayer B.J.,Rios C.B.,Baltimore D.,Cowburn D.
Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.
Proc. Natl. Acad. Sci. U.S.A.
89
11673-11677
1992
127874
Pisabarro M.T.,Ortiz A.R.,Serrano L.,Wade R.C.
Homology modeling of the Abl-SH3 domain.
Proteins
20
203-215
1994
127875
Gosser Y.Q.,Zheng J.,Overduin M.,Mayer B.J.,Cowburn D.
The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
Structure
3
1075-1086
1995
127876
Pisabarro M.T.,Serrano L.,Wilmanns M.
Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.
J. Mol. Biol.
281
513-521
1998
127877
Donaldson L.W.,Gish G.,Pawson T.,Kay L.E.,Forman-Kay J.D.
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
Proc. Natl. Acad. Sci. U.S.A.
99
14053-14058
2002
127878
Nagar B.,Hantschel O.,Young M.A.,Scheffzek K.,Veach D.,Bornmann W.,Clarkson B.,Superti-Furga G.,Kuriyan J.
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Cell
112
859-871
2003
127879
Young M.A.,Shah N.P.,Chao L.H.,Seeliger M.,Milanov Z.V.,Biggs W.H. III,Treiber D.K.,Patel H.K.,Zarrinkar P.P.,Lockhart D.J.,Sawyers C.L.,Kuriyan J.
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer Res.
66
1007-1014
2006
127880
Nagar B.,Hantschel O.,Seeliger M.,Davies J.M.,Weis W.I.,Superti-Furga G.,Kuriyan J.
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol. Cell
21
787-798
2006
127881
Levinson N.M.,Kuchment O.,Shen K.,Young M.A.,Koldobskiy M.,Karplus M.,Cole P.A.,Kuriyan J.
A Src-like inactive conformation in the abl tyrosine kinase domain.
PLoS Biol.
4
0-0
2006
127882
Cowan-Jacob S.W.,Fendrich G.,Floersheimer A.,Furet P.,Liebetanz J.,Rummel G.,Rheinberger P.,Centeleghe M.,Fabbro D.,Manley P.W.
Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
Acta Crystallogr. D
63
80-93
2007
127883
Camara-Artigas A.,Palencia A.,Martinez J.C.,Luque I.,Gavira J.A.,Garcia-Ruiz J.M.
Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.
Acta Crystallogr. D
63
646-652
2007
127884
Palencia A.,Camara-Artigas A.,Pisabarro M.T.,Martinez J.C.,Luque I.
Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
J. Biol. Chem.
285
2823-2833
2010
127885
Wojcik J.,Hantschel O.,Grebien F.,Kaupe I.,Bennett K.L.,Barkinge J.,Jones R.B.,Koide A.,Superti-Furga G.,Koide S.
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
Nat. Struct. Mol. Biol.
17
519-527
2010
127886
Graux C.,Cools J.,Melotte C.,Quentmeier H.,Ferrando A.,Levine R.,Vermeesch J.R.,Stul M.,Dutta B.,Boeckx N.,Bosly A.,Heimann P.,Uyttebroeck A.,Mentens N.,Somers R.,MacLeod R.A.,Drexler H.G.,Look A.T.,Gilliland D.G.,Michaux L.,Vandenberghe P.,Wlodarska I.,Marynen P.,Hagemeijer A.
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
Nat. Genet.
36
1084-1089
2004
127887
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
127888
Wang X.,Charng W.L.,Chen C.A.,Rosenfeld J.A.,Al Shamsi A.,Al-Gazali L.,McGuire M.,Mew N.A.,Arnold G.L.,Qu C.,Ding Y.,Muzny D.M.,Gibbs R.A.,Eng C.M.,Walkiewicz M.,Xia F.,Plon S.E.,Lupski J.R.,Schaaf C.P.,Yang Y.
Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
Nat. Genet.
49
613-617
2017
