Sequence of CERS1_MOUSE
EC Number:2.3.1.299
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
stearoyl-CoA + a sphingoid base = an N-(stearoyl)-sphingoid base + CoA
General information:
Sequence
0 MAAAAATPRL EAPEPMPSYA QMLQRSWASA LAAAQGCGDC GWGLARRGLA EHAHLAAPEL
60 LLAVLCALGW TALRWAATTH IFRPLAKRCR LQPRDAARLP ESAWKLLFYL ACWSYCAYLL
120 LGTSYPFFHD PPSVFYDWRS GMAVPWDIAV AYLLQGSFYC HSIYATVYMD SWRKDSVVML
180 VHHVVTLLLI ASSYAFRYHN VGLLVFFLHD VSDVQLEFTK LNIYFKARGG AYHRLHGLVA
240 NLGCLSFCFC WFWFRLYWFP LKVLYATCHC SLQSVPDIPY YFFFNILLLL LMVMNIYWFL
300 YIVAFAAKVL TGQMRELEDL REYDTLEAQT AKPCKAEKPL RNGLVKDKLF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
482137
Lee S.-J.
Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.
Proc. Natl. Acad. Sci. U.S.A.
88
4250-4254
1991
482138
Venkataraman K.,Riebeling C.,Bodennec J.,Riezman H.,Allegood J.C.,Sullards M.C.,Merrill A.H. Jr.,Futerman A.H.
Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.
J. Biol. Chem.
277
35642-35649
2002
482139
Mizutani Y.,Kihara A.,Igarashi Y.
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
Biochem. J.
390
263-271
2005
482140
Spassieva S.,Seo J.G.,Jiang J.C.,Bielawski J.,Alvarez-Vasquez F.,Jazwinski S.M.,Hannun Y.A.,Obeid L.M.
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
J. Biol. Chem.
281
33931-33938
2006
482141
Lahiri S.,Lee H.,Mesicek J.,Fuks Z.,Haimovitz-Friedman A.,Kolesnick R.N.,Futerman A.H.
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.
FEBS Lett.
581
5289-5294
2007
482142
Mizutani Y.,Kihara A.,Chiba H.,Tojo H.,Igarashi Y.
2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length.
J. Lipid Res.
49
2356-2364
2008
482143
Zhao L.,Spassieva S.D.,Jucius T.J.,Shultz L.D.,Shick H.E.,Macklin W.B.,Hannun Y.A.,Obeid L.M.,Ackerman S.L.
A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
PLoS Genet.
7
e1002063-e1002063
2011
482144
Novgorodov S.A.,Riley C.L.,Keffler J.A.,Yu J.,Kindy M.S.,Macklin W.B.,Lombard D.B.,Gudz T.I.
SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury.
J. Biol. Chem.
291
1957-1973
2016
482145
Turpin-Nolan S.M.,Hammerschmidt P.,Chen W.,Jais A.,Timper K.,Awazawa M.,Brodesser S.,Bruening J.C.
CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.
Cell Rep.
26
1-10
2019
