Sequence of OGA_CLOP1
EC Number:3.2.1.169
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
protein O-GlcNAcase
Q0TR53
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
1001
111080
Reaction
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O = [protein]-L-serine + N-acetyl-D-glucosamine
Other sequences found for EC No. 3.2.1.169
General information:
Sequence
0 MKRKMLKRLL TSAFACMFIA NGLITTTVRA VGPKTGEENQ VLVPNLNPTP ENLEVVGDGF
60 KITSSINLVG EEEADENAVN ALREFLTANN IEINSENDPN STTLIIGEVD DDIPELDEAL
120 NGTTAENLKE EGYALVSNDG KIAIEGKDGD GTFYGVQTFK QLVKESNIPE VNITDYPTVS
180 ARGIVEGFYG TPWTHQDRLD QIKFYGENKL NTYIYAPKDD PYHREKWREP YPESEMQRMQ
240 ELINASAENK VDFVFGISPG IDIRFDGDAG EEDFNHLITK AESLYDMGVR SFAIYWDDIQ
300 DKSAAKHAQV LNRFNEEFVK AKGDVKPLIT VPTEYDTGAM VSNGQPRAYT RIFAETVDPS
360 IEVMWTGPGV VTNEIPLSDA QLISGIYNRN MAVWWNYPVT DYFKGKLALG PMHGLDKGLN
420 QYVDFFTVNP MEHAELSKIS IHTAADYSWN MDNYDYDKAW NRAIDMLYGD LAEDMKVFAN
480 HSTRMDNKTW AKSGREDAPE LRAKMDELWN KLSSKEDASA LIEELYGEFA RMEEACNNLK
540 ANLPEVALEE CSRQLDELIT LAQGDKASLD MIVAQLNEDT EAYESAKEIA QNKLNTALSS
600 FAVISEKVAQ SFIQEALSFD LTLINPRTVK ITASSEETSG ENAPASFASD GDMNTFWHSK
660 WSSPAHEGPH HLTLELDNVY EINKVKYAPR QDSKNGRITG YKVSVSLDGE NFTEVKTGTL
720 EDNAAIKFIE FDSVDAKYVR LDVTDSVSDQ ANGRGKFATA AEVNVHGKLK ENAEVTGSVS
780 LEALEEVQVG ENLEVGVGID ELVNAEAFAY DFTLNYDENA FEYVEAISDD GVFVNAKKIE
840 DGKVRVLVSS LTGEPLPAKE VLAKVVLRAE AKAEGSNLSV TNSSVGDGEG LVHEIAGTEK
900 TVNIIEGTSP EIVVNPVRDF KASEINKKNV TVTWTEPETT EGLEGYILYK DGKKVAEIGK
960 DETSYTFKKL NRHTIYNFKI AAKYSNGEVS SKESLTLRTA R
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1224247
Myers G.S.A.,Rasko D.A.,Cheung J.K.,Ravel J.,Seshadri R.,DeBoy R.T.,Ren Q.,Varga J.,Awad M.M.,Brinkac L.M.,Daugherty S.C.,Haft D.H.,Dodson R.J.,Madupu R.,Nelson W.C.,Rosovitz M.J.,Sullivan S.A.,Khouri H.,Dimitrov G.I.,Watkins K.L.,Mulligan S.,Benton J.,Radune D.,Fisher D.J.,Atkins H.S.,Hiscox T.,Jost B.H.,Billington S.J.,Songer J.G.,McClane B.A.,Titball R.W.,Rood J.I.,Melville S.B.,Paulsen I.T.
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Genome Res.
16
1031-1040
2006
1224248
Rao F.V.,Dorfmueller H.C.,Villa F.,Allwood M.,Eggleston I.M.,van Aalten D.M.
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
EMBO J.
25
1569-1578
2006
1224249
Ficko-Blean E.,Boraston A.B.
The interaction of a carbohydrate-binding module from a Clostridium perfringens N-acetyl-beta-hexosaminidase with its carbohydrate receptor.
J. Biol. Chem.
281
37748-37757
2006
1224250
Pathak S.,Dorfmueller H.C.,Borodkin V.S.,van Aalten D.M.
Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.
Chem. Biol.
15
799-807
2008
1224251
Ficko-Blean E.,Gregg K.J.,Adams J.J.,Hehemann J.H.,Czjzek M.,Smith S.P.,Boraston A.B.
Portrait of an enzyme, a complete structural analysis of a multimodular {beta}-N-acetylglucosaminidase from Clostridium perfringens.
J. Biol. Chem.
284
9876-9884
2009
1224252
Schimpl M.,Borodkin V.S.,Gray L.J.,van Aalten D.M.
Synergy of peptide and sugar in O-GlcNAcase substrate recognition.
Chem. Biol.
19
173-178
2012
