Sequence of PARG_RAT
EC Number:3.2.1.143
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hydrolyses poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D-ribose
General information:
Sequence
0 MSAGPGCEPC TKRPRWGAAG TSAPTASDSR SFPGRQKRVL DPKDAPVQFR VPPSSSACVS
60 GRAGPHRGSV TSFVFKQKPI TTWMDTKGPK TAESESKENN NTRTDPMMSS VQKDNFYPHK
120 VEKLGNVPQL NLDKSPTEKS TPYLNQQQTA GVCKWHSAGE RAEQLSASEP SAVTQAPKQL
180 SNANIDQSPP TDGHSDTDHE EDRDNQQFLT PVKLANAKQT VGDGQARSNC KCSASCQCGQ
240 DCAGCQREEA DVIPESPLSD VGAEDIGTGS KNDNKLTGQE SGLGDSPPFE KESEPESPMD
300 VDNSKTSCQD SEADEEASPV FDEQDDQDDR SSQTANKLSS RQAREVDGDL RKRYLTKGSE
360 IRLHFQFEGG SNAGTSDLNA KPSGNSSSLN VDGRSSKQHG KRDSKITDHF VRIPKSEDKR
420 KEQCEVRHQR AERKIPKYVP PNLPPDKKWL GTPIEEMRKM PRCGVRLPLL RPSASHTVTV
480 RVDLLRAGEV PKPFPTHYKD LWDNKHVKMP CSEQNLYPVE DENGERTAGS RWELIQTALL
540 NKFTRPQNLK DAILKYNVAY SKKWDFTALV DFWDKVLEEA EAQHLYQSIL PDMVKIALCL
600 PNICTQPIPL LKQKMNHSVT MSQEQIASLL ANAFFCTFPR RNAKMKSEYS SYPDINFNRL
660 FEGRSSRKPE KLKTLFCYFR RVTEKKPTGL VTFTRQSLED FPEWERCDKP LTRLHVTYEG
720 TIEGNGRGML QVDFANRFVG GGVTGAGLVQ EEIRFLINPE LIVSRLFTEV LDHNECLIIT
780 GTEQYSEYTG YAETYRWARS HEDGSEKDDW QRCCTEIVAI DALHFRRYLD QFVPEKVRRE
840 LNKAYCGFLR PGVPPENLSA VATGNWGCGA FGGDARLKAL IQLLAAAAAE RDVVYFTFGD
900 SELMRDIYSM HTFLTERKLN VGKVYRLLLR YYREECRDCS SPGPDTKLYP FIYHAAESSA
960 ETSDQPGQRT GT
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1257290
Shimokawa T.,Masutani M.,Nagasawa S.,Nozaki T.,Ikota N.,Aoki Y.,Nakagama H.,Sugimura T.
Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs.
J. Biochem.
126
748-755
1999
1257291
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
1257292
Kim I.K.,Kiefer J.R.,Ho C.M.,Stegeman R.A.,Classen S.,Tainer J.A.,Ellenberger T.
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Nat. Struct. Mol. Biol.
19
653-656
2012
