Sequence of TREX1_HUMAN
EC Number:3.1.11.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates
General information:
Sequence
0 MGSQALPPGP MQTLIFFDME ATGLPFSQPK VTELCLLAVH RCALESPPTS QGPPPTVPPP
60 PRVVDKLSLC VAPGKACSPA ASEITGLSTA VLAAHGRQCF DDNLANLLLA FLRRQPQPWC
120 LVAHNGDRYD FPLLQAELAM LGLTSALDGA FCVDSITALK ALERASSPSE HGPRKSYSLG
180 SIYTRLYGQS PPDSHTAEGD VLALLSICQW RPQALLRWVD AHARPFGTIR PMYGVTASAR
240 TKPRPSAVTT TAHLATTRNT SPSLGESRGT KDLPPVKDPG ALSREGLLAP LGLLAILTLA
300 VATLYGLSLA TPGE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1244169
Hoess M.,Robins P.,Naven T.J.P.,Pappin D.J.C.,Sgouros J.,Lindahl T.
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.
EMBO J.
18
3868-3875
1999
1244170
Mazur D.J.,Perrino F.W.
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.
J. Biol. Chem.
274
19655-19660
1999
1244171
Mazur D.J.,Perrino F.W.
Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes.
J. Biol. Chem.
276
14718-14727
2001
1244172
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1244173
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
1244175
Muzny D.M.,Scherer S.E.,Kaul R.,Wang J.,Yu J.,Sudbrak R.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Wei S.,Wheeler D.A.,Wright M.W.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clendenning J.,Clerc-Blankenburg K.P.,Chen R.,Chen Z.,Davis C.,Delgado O.,Dinh H.H.,Dong W.,Draper H.,Ernst S.,Fu G.,Gonzalez-Garay M.L.,Garcia D.K.,Gillett W.,Gu J.,Hao B.,Haugen E.,Havlak P.,He X.,Hennig S.,Hu S.,Huang W.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Kube M.,Levy R.,Li Z.,Liu B.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Palmeiri A.,Pasternak S.,Perez L.M.,Phelps K.A.,Plopper F.J.,Qiang B.,Raymond C.,Rodriguez R.,Saenphimmachak C.,Santibanez J.,Shen H.,Shen Y.,Subramanian S.,Tabor P.E.,Verduzco D.,Waldron L.,Wang J.,Wang J.,Wang Q.,Williams G.A.,Wong G.K.-S.,Yao Z.,Zhang J.,Zhang X.,Zhao G.,Zhou J.,Zhou Y.,Nelson D.,Lehrach H.,Reinhardt R.,Naylor S.L.,Yang H.,Olson M.,Weinstock G.,Gibbs R.A.
The DNA sequence, annotation and analysis of human chromosome 3.
Nature
440
1194-1198
2006
1244176
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1244177
Chowdhury D.,Beresford P.J.,Zhu P.,Zhang D.,Sung J.S.,Demple B.,Perrino F.W.,Lieberman J.
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.
Mol. Cell
23
133-142
2006
1244178
Yang Y.G.,Lindahl T.,Barnes D.E.
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
Cell
131
873-886
2007
1244179
de Silva U.,Choudhury S.,Bailey S.L.,Harvey S.,Perrino F.W.,Hollis T.
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
J. Biol. Chem.
282
10537-10543
2007
1244180
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1244181
Gehrke N.,Mertens C.,Zillinger T.,Wenzel J.,Bald T.,Zahn S.,Tueting T.,Hartmann G.,Barchet W.
Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.
Immunity
39
482-495
2013
1244182
Orebaugh C.D.,Fye J.M.,Harvey S.,Hollis T.,Wilkinson J.C.,Perrino F.W.
The TREX1 C-terminal region controls cellular localization through ubiquitination.
J. Biol. Chem.
288
28881-28892
2013
1244183
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1244184
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1244185
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
1244186
Mohr L.,Toufektchan E.,von Morgen P.,Chu K.,Kapoor A.,Maciejowski J.
ER-directed TREX1 limits cGAS activation at micronuclei.
Mol. Cell
81
724-738
2021
1244187
Crow Y.J.,Hayward B.E.,Parmar R.,Robins P.,Leitch A.,Ali M.,Black D.N.,van Bokhoven H.,Brunner H.G.,Hamel B.C.J.,Corry P.C.,Cowan F.M.,Frints S.G.,Klepper J.,Livingston J.H.,Lynch S.A.,Massey R.F.,Meritet J.F.,Michaud J.L.,Ponsot G.,Voit T.,Lebon P.,Bonthron D.T.,Jackson A.P.,Barnes D.E.,Lindahl T.
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus.
Nat. Genet.
38
917-920
2006
1244188
Rice G.,Newman W.G.,Dean J.,Patrick T.,Parmar R.,Flintoff K.,Robins P.,Harvey S.,Hollis T.,O'Hara A.,Herrick A.L.,Bowden A.P.,Perrino F.W.,Lindahl T.,Barnes D.E.,Crow Y.J.
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.
Am. J. Hum. Genet.
80
811-815
2007
1244189
Rice G.,Patrick T.,Parmar R.,Taylor C.F.,Aeby A.,Aicardi J.,Artuch R.,Montalto S.A.,Bacino C.A.,Barroso B.,Baxter P.,Benko W.S.,Bergmann C.,Bertini E.,Biancheri R.,Blair E.M.,Blau N.,Bonthron D.T.,Briggs T.,Brueton L.A.,Brunner H.G.,Burke C.J.,Carr I.M.,Carvalho D.R.,Chandler K.E.,Christen H.J.,Corry P.C.,Cowan F.M.,Cox H.,D'Arrigo S.,Dean J.,De Laet C.,De Praeter C.,Dery C.,Ferrie C.D.,Flintoff K.,Frints S.G.,Garcia-Cazorla A.,Gener B.,Goizet C.,Goutieres F.,Green A.J.,Guet A.,Hamel B.C.,Hayward B.E.,Heiberg A.,Hennekam R.C.,Husson M.,Jackson A.P.,Jayatunga R.,Jiang Y.H.,Kant S.G.,Kao A.,King M.D.,Kingston H.M.,Klepper J.,van der Knaap M.S.,Kornberg A.J.,Kotzot D.,Kratzer W.,Lacombe D.,Lagae L.,Landrieu P.G.,Lanzi G.,Leitch A.,Lim M.J.,Livingston J.H.,Lourenco C.M.,Lyall E.G.,Lynch S.A.,Lyons M.J.,Marom D.,McClure J.P.,McWilliam R.,Melancon S.B.,Mewasingh L.D.,Moutard M.L.,Nischal K.K.,Ostergaard J.R.,Prendiville J.,Rasmussen M.,Rogers R.C.,Roland D.,Rosser E.M.,Rostasy K.,Roubertie A.,Sanchis A.,Schiffmann R.,Scholl-Burgi S.,Seal S.,Shalev S.A.,Corcoles C.S.,Sinha G.P.,Soler D.,Spiegel R.,Stephenson J.B.,Tacke U.,Tan T.Y.,Till M.,Tolmie J.L.,Tomlin P.,Vagnarelli F.,Valente E.M.,Van Coster R.N.,Van der Aa N.,Vanderver A.,Vles J.S.,Voit T.,Wassmer E.,Weschke B.,Whiteford M.L.,Willemsen M.A.,Zankl A.,Zuberi S.M.,Orcesi S.,Fazzi E.,Lebon P.,Crow Y.J.
Clinical and molecular phenotype of Aicardi-Goutieres syndrome.
Am. J. Hum. Genet.
81
713-725
2007
1244190
Lee-Kirsch M.A.,Chowdhury D.,Harvey S.,Gong M.,Senenko L.,Engel K.,Pfeiffer C.,Hollis T.,Gahr M.,Perrino F.W.,Lieberman J.,Hubner N.
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.
J. Mol. Med.
85
531-537
2007
1244191
Lee-Kirsch M.A.,Gong M.,Chowdhury D.,Senenko L.,Engel K.,Lee Y.A.,de Silva U.,Bailey S.L.,Witte T.,Vyse T.J.,Kere J.,Pfeiffer C.,Harvey S.,Wong A.,Koskenmies S.,Hummel O.,Rohde K.,Schmidt R.E.,Dominiczak A.F.,Gahr M.,Hollis T.,Perrino F.W.,Lieberman J.,Huebner N.
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Nat. Genet.
39
1065-1067
2007
1244192
Richards A.,van den Maagdenberg A.M.J.M.,Jen J.C.,Kavanagh D.,Bertram P.,Spitzer D.,Liszewski M.K.,Barilla-Labarca M.-L.,Terwindt G.M.,Kasai Y.,McLellan M.,Grand M.G.,Vanmolkot K.R.J.,de Vries B.,Wan J.,Kane M.J.,Mamsa H.,Schaefer R.,Stam A.H.,Haan J.,de Jong P.T.V.M.,Storimans C.W.,van Schooneveld M.J.,Oosterhuis J.A.,Gschwendter A.,Dichgans M.,Kotschet K.E.,Hodgkinson S.,Hardy T.A.,Delatycki M.B.,Hajj-Ali R.A.,Kothari P.H.,Nelson S.F.,Frants R.R.,Baloh R.W.,Ferrari M.D.,Atkinson J.P.
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.
Nat. Genet.
39
1068-1070
2007
1244193
Haaxma C.A.,Crow Y.J.,van Steensel M.A.,Lammens M.M.,Rice G.I.,Verbeek M.M.,Willemsen M.A.
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutieres syndrome.
Am. J. Med. Genet. A
152
2612-2617
2010
1244194
Ramantani G.,Kohlhase J.,Hertzberg C.,Innes A.M.,Engel K.,Hunger S.,Borozdin W.,Mah J.K.,Ungerath K.,Walkenhorst H.,Richardt H.H.,Buckard J.,Bevot A.,Siegel C.,von Stuelpnagel C.,Ikonomidou C.,Thomas K.,Proud V.,Niemann F.,Wieczorek D.,Haeusler M.,Niggemann P.,Baltaci V.,Conrad K.,Lebon P.,Lee-Kirsch M.A.
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome.
Arthritis Rheum.
62
1469-1477
2010
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