Sequence of IFIH1_HUMAN
EC Number:3.6.4.13
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a nucleoside triphosphate + H2O = a nucleoside diphosphate + phosphate
Other sequences found for EC No. 3.6.4.13
General information:
Sequence
0 MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV ATSGNMQAVE
60 LLLSTLEKGV WHLGWTREFV EALRRTGSPL AARYMNPELT DLPSPSFENA HDEYLQLLNL
120 LQPTLVDKLL VRDVLDKCME EELLTIEDRN RIAAAENNGN ESGVRELLKR IVQKENWFSA
180 FLNVLRQTGN NELVQELTGS DCSESNAEIE NLSQVDGPQV EEQLLSTTVQ PNLEKEVWGM
240 ENNSSESSFA DSSVVSESDT SLAEGSVSCL DESLGHNSNM GSDSGTMGSD SDEENVAARA
300 SPEPELQLRP YQMEVAQPAL EGKNIIICLP TGSGKTRVAV YIAKDHLDKK KKASEPGKVI
360 VLVNKVLLVE QLFRKEFQPF LKKWYRVIGL SGDTQLKISF PEVVKSCDII ISTAQILENS
420 LLNLENGEDA GVQLSDFSLI IIDECHHTNK EAVYNNIMRH YLMQKLKNNR LKKENKPVIP
480 LPQILGLTAS PGVGGATKQA KAEEHILKLC ANLDAFTIKT VKENLDQLKN QIQEPCKKFA
540 IADATREDPF KEKLLEIMTR IQTYCQMSPM SDFGTQPYEQ WAIQMEKKAA KEGNRKERVC
600 AEHLRKYNEA LQINDTIRMI DAYTHLETFY NEEKDKKFAV IEDDSDEGGD DEYCDGDEDE
660 DDLKKPLKLD ETDRFLMTLF FENNKMLKRL AENPEYENEK LTKLRNTIME QYTRTEESAR
720 GIIFTKTRQS AYALSQWITE NEKFAEVGVK AHHLIGAGHS SEFKPMTQNE QKEVISKFRT
780 GKINLLIATT VAEEGLDIKE CNIVIRYGLV TNEIAMVQAR GRARADESTY VLVAHSGSGV
840 IEHETVNDFR EKMMYKAIHC VQNMKPEEYA HKILELQMQS IMEKKMKTKR NIAKHYKNNP
900 SLITFLCKNC SVLACSGEDI HVIEKMHHVN MTPEFKELYI VRENKALQKK CADYQINGEI
960 ICKCGQAWGT MMVHKGLDLP CLKIRNFVVV FKNNSTKKQY KKWVELPITF PNLDYSECCL
1020 FSDED
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1200845
Kang D.-C.,Gopalkrishnan R.V.,Wu Q.,Jankowsky E.,Pyle A.M.,Fisher P.B.
mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
Proc. Natl. Acad. Sci. U.S.A.
99
637-642
2002
1200846
Cocude C.,Truong M.-J.,Billaut-Mulot O.,Delsart V.,Darcissac E.,Capron A.,Mouton Y.,Bahr G.M.
A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.
J. Gen. Virol.
84
3215-3225
2003
1200847
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1200848
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1200849
Kovacsovics M.,Martinon F.,Micheau O.,Bodmer J.-L.,Hofmann K.,Tschopp J.
Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
Curr. Biol.
12
838-843
2002
1200851
Andrejeva J.,Childs K.S.,Young D.F.,Carlos T.S.,Stock N.,Goodbourn S.,Randall R.E.
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
Proc. Natl. Acad. Sci. U.S.A.
101
17264-17269
2004
1200852
Kawai T.,Takahashi K.,Sato S.,Coban C.,Kumar H.,Kato H.,Ishii K.J.,Takeuchi O.,Akira S.
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nat. Immunol.
6
981-988
2005
1200853
Meylan E.,Curran J.,Hofmann K.,Moradpour D.,Binder M.,Bartenschlager R.,Tschopp J.
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Nature
437
1167-1172
2005
1200854
Arimoto K.,Takahashi H.,Hishiki T.,Konishi H.,Fujita T.,Shimotohno K.
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
Proc. Natl. Acad. Sci. U.S.A.
104
7500-7505
2007
1200855
Diao F.,Li S.,Tian Y.,Zhang M.,Xu L.G.,Zhang Y.,Wang R.P.,Chen D.,Zhai Z.,Zhong B.,Tien P.,Shu H.B.
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.
Proc. Natl. Acad. Sci. U.S.A.
104
11706-11711
2007
1200856
Jounai N.,Takeshita F.,Kobiyama K.,Sawano A.,Miyawaki A.,Xin K.Q.,Ishii K.J.,Kawai T.,Akira S.,Suzuki K.,Okuda K.
The Atg5-Atg12 conjugate associates with innate antiviral immune responses.
Proc. Natl. Acad. Sci. U.S.A.
104
14050-14055
2007
1200857
Sato S.,Hoshino K.,Satoh T.,Fujita T.,Kawakami Y.,Fujita T.,Kuwana M.
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Arthritis Rheum.
60
2193-2200
2009
1200858
Bamming D.,Horvath C.M.
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
J. Biol. Chem.
284
9700-9712
2009
1200859
Pichlmair A.,Schulz O.,Tan C.P.,Rehwinkel J.,Kato H.,Takeuchi O.,Akira S.,Way M.,Schiavo G.,Reis e Sousa C.
Activation of MDA5 requires higher-order RNA structures generated during virus infection.
J. Virol.
83
10761-10769
2009
1200860
You F.,Sun H.,Zhou X.,Sun W.,Liang S.,Zhai Z.,Jiang Z.
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.
Nat. Immunol.
10
1300-1308
2009
1200861
Cui J.,Zhu L.,Xia X.,Wang H.Y.,Legras X.,Hong J.,Ji J.,Shen P.,Zheng S.,Chen Z.J.,Wang R.F.
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Cell
141
483-496
2010
1200862
Chen R.,Zhang L.,Zhong B.,Tan B.,Liu Y.,Shu H.B.
The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
Cell Res.
20
802-811
2010
1200863
Oshiumi H.,Sakai K.,Matsumoto M.,Seya T.
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
Eur. J. Immunol.
40
940-948
2010
1200864
Nakashima R.,Imura Y.,Kobayashi S.,Yukawa N.,Yoshifuji H.,Nojima T.,Kawabata D.,Ohmura K.,Usui T.,Fujii T.,Okawa K.,Mimori T.
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.
Rheumatology
49
433-440
2010
1200865
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
1200866
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1200868
Kato H.,Takahasi K.,Fujita T.
RIG-I-like receptors: cytoplasmic sensors for non-self RNA.
Immunol. Rev.
243
91-98
2011
1200869
Jiang M.,Osterlund P.,Sarin L.P.,Poranen M.M.,Bamford D.H.,Guo D.,Julkunen I.
Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5' phosphorylation of RNA molecules.
J. Immunol.
187
1713-1721
2011
1200870
Onoguchi K.,Yoneyama M.,Fujita T.
Retinoic acid-inducible gene-I-like receptors.
J. Interferon Cytokine Res.
31
27-31
2011
1200871
Miyashita M.,Oshiumi H.,Matsumoto M.,Seya T.
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
Mol. Cell. Biol.
31
3802-3819
2011
1200872
Fu J.,Xiong Y.,Xu Y.,Cheng G.,Tang H.
MDA5 is SUMOylated by PIAS2? in the upregulation of type I interferon signaling.
Mol. Immunol.
48
415-422
2011
1200873
Garcia-Sastre A.
2 methylate or not 2 methylate: viral evasion of the type I interferon response.
Nat. Immunol.
12
114-115
2011
1200874
Zuest R.,Cervantes-Barragan L.,Habjan M.,Maier R.,Neuman B.W.,Ziebuhr J.,Szretter K.J.,Baker S.C.,Barchet W.,Diamond M.S.,Siddell S.G.,Ludewig B.,Thiel V.
Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
Nat. Immunol.
12
137-143
2011
1200875
Peisley A.,Lin C.,Wu B.,Orme-Johnson M.,Liu M.,Walz T.,Hur S.
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.
Proc. Natl. Acad. Sci. U.S.A.
108
21010-21015
2011
1200876
Xing J.,Wang S.,Lin R.,Mossman K.L.,Zheng C.
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.
J. Virol.
86
3528-3540
2012
1200877
Menning M.,Kufer T.A.
A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
FEBS Lett.
587
2137-2142
2013
1200878
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1200879
Feng Q.,Langereis M.A.,Lork M.,Nguyen M.,Hato S.V.,Lanke K.,Emdad L.,Bhoopathi P.,Fisher P.B.,Lloyd R.E.,van Kuppeveld F.J.
Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
J. Virol.
88
3369-3378
2014
1200880
Takashima K.,Oshiumi H.,Takaki H.,Matsumoto M.,Seya T.
RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
Cell Rep.
11
192-200
2015
1200881
Wang S.,Yang Y.K.,Chen T.,Zhang H.,Yang W.W.,Song S.S.,Zhai Z.H.,Chen D.Y.
RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.
EMBO Rep.
17
1155-1168
2016
1200882
Rui Y.,Su J.,Wang H.,Chang J.,Wang S.,Zheng W.,Cai Y.,Wei W.,Gordy J.T.,Markham R.,Kong W.,Zhang W.,Yu X.F.
Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68.
J. Virol.
91
0-0
2017
1200883
Zhao C.,Jia M.,Song H.,Yu Z.,Wang W.,Li Q.,Zhang L.,Zhao W.,Cao X.
The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
Cell Rep.
21
1613-1623
2017
1200884
Li L.,Fan H.,Song Z.,Liu X.,Bai J.,Jiang P.
Encephalomyocarditis virus 2C protein antagonizes interferon-beta signaling pathway through interaction with MDA5.
Antiviral Res.
161
70-84
2018
1200885
Lian H.,Zang R.,Wei J.,Ye W.,Hu M.M.,Chen Y.D.,Zhang X.N.,Guo Y.,Lei C.Q.,Yang Q.,Luo W.W.,Li S.,Shu H.B.
The zinc-finger protein ZCCHC3 binds RNA and facilitates viral RNA sensing and activation of the RIG-I-like receptors.
Immunity
49
438-448
2018
1200886
Wu X.M.,Zhang J.,Li P.W.,Hu Y.W.,Cao L.,Ouyang S.,Bi Y.H.,Nie P.,Chang M.X.
NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS.
J. Immunol.
204
2216-2231
2020
1200887
Yin X.,Riva L.,Pu Y.,Martin-Sancho L.,Kanamune J.,Yamamoto Y.,Sakai K.,Gotoh S.,Miorin L.,De Jesus P.D.,Yang C.C.,Herbert K.M.,Yoh S.,Hultquist J.F.,Garcia-Sastre A.,Chanda S.K.
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
Cell Rep.
34
108628-108628
2021
1200888
Rebendenne A.,Valadao A.L.C.,Tauziet M.,Maarifi G.,Bonaventure B.,McKellar J.,Planes R.,Nisole S.,Arnaud-Arnould M.,Moncorge O.,Goujon C.
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
J. Virol.
0
0-0
2021
1200889
Liu G.,Lee J.H.,Parker Z.M.,Acharya D.,Chiang J.J.,van Gent M.,Riedl W.,Davis-Gardner M.E.,Wies E.,Chiang C.,Gack M.U.
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Nat. Microbiol.
6
467-478
2021
1200890
Li X.,Lu C.,Stewart M.,Xu H.,Strong R.K.,Igumenova T.,Li P.
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.
Arch. Biochem. Biophys.
488
23-33
2009
1200891
Takahasi K.,Kumeta H.,Tsuduki N.,Narita R.,Shigemoto T.,Hirai R.,Yoneyama M.,Horiuchi M.,Ogura K.,Fujita T.,Inagaki F.
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.
J. Biol. Chem.
284
17465-17474
2009
1200893
Smyth D.J.,Cooper J.D.,Bailey R.,Field S.,Burren O.,Smink L.J.,Guja C.,Ionescu-Tirgoviste C.,Widmer B.,Dunger D.B.,Savage D.A.,Walker N.M.,Clayton D.G.,Todd J.A.
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Nat. Genet.
38
617-619
2006
1200894
Oda H.,Nakagawa K.,Abe J.,Awaya T.,Funabiki M.,Hijikata A.,Nishikomori R.,Funatsuka M.,Ohshima Y.,Sugawara Y.,Yasumi T.,Kato H.,Shirai T.,Ohara O.,Fujita T.,Heike T.
Aicardi-Goutieres syndrome is caused by IFIH1 mutations.
Am. J. Hum. Genet.
95
121-125
2014
1200895
Rice G.I.,del Toro Duany Y.,Jenkinson E.M.,Forte G.M.,Anderson B.H.,Ariaudo G.,Bader-Meunier B.,Baildam E.M.,Battini R.,Beresford M.W.,Casarano M.,Chouchane M.,Cimaz R.,Collins A.E.,Cordeiro N.J.,Dale R.C.,Davidson J.E.,De Waele L.,Desguerre I.,Faivre L.,Fazzi E.,Isidor B.,Lagae L.,Latchman A.R.,Lebon P.,Li C.,Livingston J.H.,Lourenco C.M.,Mancardi M.M.,Masurel-Paulet A.,McInnes I.B.,Menezes M.P.,Mignot C.,O'Sullivan J.,Orcesi S.,Picco P.P.,Riva E.,Robinson R.A.,Rodriguez D.,Salvatici E.,Scott C.,Szybowska M.,Tolmie J.L.,Vanderver A.,Vanhulle C.,Vieira J.P.,Webb K.,Whitney R.N.,Williams S.G.,Wolfe L.A.,Zuberi S.M.,Hur S.,Crow Y.J.
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling.
Nat. Genet.
46
503-509
2014
1200896
Rutsch F.,MacDougall M.,Lu C.,Buers I.,Mamaeva O.,Nitschke Y.,Rice G.I.,Erlandsen H.,Kehl H.G.,Thiele H.,Nurnberg P.,Hohne W.,Crow Y.J.,Feigenbaum A.,Hennekam R.C.
A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome.
Am. J. Hum. Genet.
96
275-282
2015
