Sequence of SPHK1_RAT
EC Number:2.7.1.91
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
General information:
Sequence
0 MQPADCPRGL LPRPCRVLVL LNPRGGKGKA LKLFQSRVRP LLEEAEVSFK LMLTERQNHA
60 RELVCAEELG HWDALAVMSG DGLMHEVVNG LMERPDWESA IQKPLCSLPG GSGNALAASL
120 NYYAGHEQVT NEDLLINCTL LLCCRQLSPM NLLSLHTASG RQLYSVLSLS WGFVADVDLE
180 SEKYRSLGEI RFTVGTFFRL ASLRIYQGQL AYLPVGKAAS KIPASSLAQK GPANTYLVPL
240 EEPVPPHWTV VPEQDFVLVL VLLHTHLSTE MFAAPMGRCE AGVMHLFYIR AGVSRAMLVR
300 LFLAMQKGKH MDLDCPYLVH VPVVAFRLEP RNQRGVFSVD GELMVCEAVQ GQVHPNYLWM
360 VSGSSDSPSG RDSQRRPPPE EPI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1116758
Imamura T.,Ohgane J.,Ito S.,Ogawa T.,Hattori N.,Tanaka S.,Shiota K.
CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons.
Genomics
76
117-125
2001
1116759
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1116760
Maceyka M.,Sankala H.,Hait N.C.,Le Stunff H.,Liu H.,Toman R.,Collier C.,Zhang M.,Satin L.S.,Merrill A.H. Jr.,Milstien S.,Spiegel S.
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
J. Biol. Chem.
280
37118-37129
2005
1116761
Cieslik M.,Czapski G.A.,Strosznajder J.B.
The Molecular Mechanism of Amyloid beta42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins.
PLoS ONE
10
E0137193-E0137193
2015
1116762
Su D.,Cheng Y.,Li S.,Dai D.,Zhang W.,Lv M.
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-kappaB pathways in activated microglia in cerebral ischemia reperfusion.
J. Neuroimmunol.
305
35-41
2017
