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Sequence of SUV91_HUMAN

EC Number:2.1.1.355

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
[histone H3]-lysine9 N-trimethyltransferase
O43463
Homo sapiens
412
47907
Reaction
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Other sequences found for EC No. 2.1.1.355

General information:

Sequence
show sequence in fasta format
  0 MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY
 60 LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ
120 KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG
180 CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG
240 IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD
300 LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE
360 LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1129739
Aagaard L.,Laible G.,Selenko P.,Schmid M.,Dorn R.,Schotta G.,Kuhfittig S.,Wolf A.,Lebersorger A.,Singh P.B.,Reuter G.,Jenuwein T.
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.
EMBO J.
18
1923-1938
1999
1129741
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1129743
Ross M.T.,Grafham D.V.,Coffey A.J.,Scherer S.,McLay K.,Muzny D.,Platzer M.,Howell G.R.,Burrows C.,Bird C.P.,Frankish A.,Lovell F.L.,Howe K.L.,Ashurst J.L.,Fulton R.S.,Sudbrak R.,Wen G.,Jones M.C.,Hurles M.E.,Andrews T.D.,Scott C.E.,Searle S.,Ramser J.,Whittaker A.,Deadman R.,Carter N.P.,Hunt S.E.,Chen R.,Cree A.,Gunaratne P.,Havlak P.,Hodgson A.,Metzker M.L.,Richards S.,Scott G.,Steffen D.,Sodergren E.,Wheeler D.A.,Worley K.C.,Ainscough R.,Ambrose K.D.,Ansari-Lari M.A.,Aradhya S.,Ashwell R.I.,Babbage A.K.,Bagguley C.L.,Ballabio A.,Banerjee R.,Barker G.E.,Barlow K.F.,Barrett I.P.,Bates K.N.,Beare D.M.,Beasley H.,Beasley O.,Beck A.,Bethel G.,Blechschmidt K.,Brady N.,Bray-Allen S.,Bridgeman A.M.,Brown A.J.,Brown M.J.,Bonnin D.,Bruford E.A.,Buhay C.,Burch P.,Burford D.,Burgess J.,Burrill W.,Burton J.,Bye J.M.,Carder C.,Carrel L.,Chako J.,Chapman J.C.,Chavez D.,Chen E.,Chen G.,Chen Y.,Chen Z.,Chinault C.,Ciccodicola A.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Clerc-Blankenburg K.,Clifford K.,Cobley V.,Cole C.G.,Conquer J.S.,Corby N.,Connor R.E.,David R.,Davies J.,Davis C.,Davis J.,Delgado O.,Deshazo D.,Dhami P.,Ding Y.,Dinh H.,Dodsworth S.,Draper H.,Dugan-Rocha S.,Dunham A.,Dunn M.,Durbin K.J.,Dutta I.,Eades T.,Ellwood M.,Emery-Cohen A.,Errington H.,Evans K.L.,Faulkner L.,Francis F.,Frankland J.,Fraser A.E.,Galgoczy P.,Gilbert J.,Gill R.,Gloeckner G.,Gregory S.G.,Gribble S.,Griffiths C.,Grocock R.,Gu Y.,Gwilliam R.,Hamilton C.,Hart E.A.,Hawes A.,Heath P.D.,Heitmann K.,Hennig S.,Hernandez J.,Hinzmann B.,Ho S.,Hoffs M.,Howden P.J.,Huckle E.J.,Hume J.,Hunt P.J.,Hunt A.R.,Isherwood J.,Jacob L.,Johnson D.,Jones S.,de Jong P.J.,Joseph S.S.,Keenan S.,Kelly S.,Kershaw J.K.,Khan Z.,Kioschis P.,Klages S.,Knights A.J.,Kosiura A.,Kovar-Smith C.,Laird G.K.,Langford C.,Lawlor S.,Leversha M.,Lewis L.,Liu W.,Lloyd C.,Lloyd D.M.,Loulseged H.,Loveland J.E.,Lovell J.D.,Lozado R.,Lu J.,Lyne R.,Ma J.,Maheshwari M.,Matthews L.H.,McDowall J.,McLaren S.,McMurray A.,Meidl P.,Meitinger T.,Milne S.,Miner G.,Mistry S.L.,Morgan M.,Morris S.,Mueller I.,Mullikin J.C.,Nguyen N.,Nordsiek G.,Nyakatura G.,O'dell C.N.,Okwuonu G.,Palmer S.,Pandian R.,Parker D.,Parrish J.,Pasternak S.,Patel D.,Pearce A.V.,Pearson D.M.,Pelan S.E.,Perez L.,Porter K.M.,Ramsey Y.,Reichwald K.,Rhodes S.,Ridler K.A.,Schlessinger D.,Schueler M.G.,Sehra H.K.,Shaw-Smith C.,Shen H.,Sheridan E.M.,Shownkeen R.,Skuce C.D.,Smith M.L.,Sotheran E.C.,Steingruber H.E.,Steward C.A.,Storey R.,Swann R.M.,Swarbreck D.,Tabor P.E.,Taudien S.,Taylor T.,Teague B.,Thomas K.,Thorpe A.,Timms K.,Tracey A.,Trevanion S.,Tromans A.C.,d'Urso M.,Verduzco D.,Villasana D.,Waldron L.,Wall M.,Wang Q.,Warren J.,Warry G.L.,Wei X.,West A.,Whitehead S.L.,Whiteley M.N.,Wilkinson J.E.,Willey D.L.,Williams G.,Williams L.,Williamson A.,Williamson H.,Wilming L.,Woodmansey R.L.,Wray P.W.,Yen J.,Zhang J.,Zhou J.,Zoghbi H.,Zorilla S.,Buck D.,Reinhardt R.,Poustka A.,Rosenthal A.,Lehrach H.,Meindl A.,Minx P.J.,Hillier L.W.,Willard H.F.,Wilson R.K.,Waterston R.H.,Rice C.M.,Vaudin M.,Coulson A.,Nelson D.L.,Weinstock G.,Sulston J.E.,Durbin R.M.,Hubbard T.,Gibbs R.A.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence of the human X chromosome.
Nature
434
325-337
2005
1129745
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1129746
Aagaard L.,Schmid M.,Warburton P.,Jenuwein T.
Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres.
J. Cell Sci.
113
817-829
2000
1129747
Rea S.,Eisenhaber F.,O'Carroll D.,Strahl B.D.,Sun Z.-W.,Schmid M.,Opravil S.,Mechtler K.,Ponting C.P.,Allis C.D.,Jenuwein T.
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Nature
406
593-599
2000
1129748
Firestein R.,Cui X.,Huie P.,Cleary M.L.
Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.
Mol. Cell. Biol.
20
4900-4909
2000
1129749
Lachner M.,O'Carroll D.,Rea S.,Mechtler K.,Jenuwein T.
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Nature
410
116-120
2001
1129750
Nielsen S.J.,Schneider R.,Bauer U.-M.,Bannister A.J.,Morrison A.,O'Carroll D.,Firestein R.,Cleary M.L.,Jenuwein T.,Herrera R.E.,Kouzarides T.
Rb targets histone H3 methylation and HP1 to promoters.
Nature
412
561-565
2001
1129751
Fujita N.,Watanabe S.,Ichimura T.,Tsuruzoe S.,Shinkai Y.,Tachibana M.,Chiba T.,Nakao M.
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.
J. Biol. Chem.
278
24132-24138
2003
1129752
Sewalt R.G.A.B.,Lachner M.,Vargas M.,Hamer K.M.,den Blaauwen J.L.,Hendrix T.,Melcher M.,Schweizer D.,Jenuwein T.,Otte A.P.
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.
Mol. Cell. Biol.
22
5539-5553
2002
1129753
Chakraborty S.,Sinha K.K.,Senyuk V.,Nucifora G.
SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo.
Oncogene
22
5229-5237
2003
1129754
Macaluso M.,Cinti C.,Russo G.,Russo A.,Giordano A.
pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
Oncogene
22
3511-3517
2003
1129755
Ait-Si-Ali S.,Guasconi V.,Fritsch L.,Yahi H.,Sekhri R.,Naguibneva I.,Robin P.,Cabon F.,Polesskaya A.,Harel-Bellan A.
A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.
EMBO J.
23
605-615
2004
1129756
Frontelo P.,Leader J.E.,Yoo N.,Potocki A.C.,Crawford M.,Kulik M.,Lechleider R.J.
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
Oncogene
23
5242-5251
2004
1129757
Krouwels I.M.,Wiesmeijer K.,Abraham T.E.,Molenaar C.,Verwoerd N.P.,Tanke H.J.,Dirks R.W.
A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.
J. Cell Biol.
170
537-549
2005
1129758
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
1129759
Vassen L.,Fiolka K.,Moeroey T.
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
EMBO J.
25
2409-2419
2006
1129760
Bradley S.P.,Kaminski D.A.,Peters A.H.F.M.,Jenuwein T.,Stavnezer J.
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
J. Immunol.
177
1179-1188
2006
1129761
Chin H.G.,Patnaik D.,Esteve P.-O.,Jacobsen S.E.,Pradhan S.
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.
Biochemistry
45
3272-3284
2006
1129762
Mal A.K.
Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.
EMBO J.
25
3323-3334
2006
1129763
Carbone R.,Botrugno O.A.,Ronzoni S.,Insinga A.,Di Croce L.,Pelicci P.G.,Minucci S.
Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
Mol. Cell. Biol.
26
1288-1296
2006
1129764
Reed-Inderbitzin E.,Moreno-Miralles I.,Vanden-Eynden S.K.,Xie J.,Lutterbach B.,Durst-Goodwin K.L.,Luce K.S.,Irvin B.J.,Cleary M.L.,Brandt S.J.,Hiebert S.W.
RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.
Oncogene
25
5777-5786
2006
1129765
Kamoi K.,Yamamoto K.,Misawa A.,Miyake A.,Ishida T.,Tanaka Y.,Mochizuki M.,Watanabe T.
SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR.
Retrovirology
3
5-5
2006
1129766
Vaquero A.,Scher M.,Erdjument-Bromage H.,Tempst P.,Serrano L.,Reinberg D.
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Nature
450
440-444
2007
1129767
Murayama A.,Ohmori K.,Fujimura A.,Minami H.,Yasuzawa-Tanaka K.,Kuroda T.,Oie S.,Daitoku H.,Okuwaki M.,Nagata K.,Fukamizu A.,Kimura K.,Shimizu T.,Yanagisawa J.
Epigenetic control of rDNA loci in response to intracellular energy status.
Cell
133
627-639
2008
1129768
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1129769
Li Z.,Chen L.,Kabra N.,Wang C.,Fang J.,Chen J.
Inhibition of SUV39H1 methyltransferase activity by DBC1.
J. Biol. Chem.
284
10361-10366
2009
1129770
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
1129771
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
1129772
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
1129773
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
1129774
Liu B.,Wang Z.,Zhang L.,Ghosh S.,Zheng H.,Zhou Z.
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
Nat. Commun.
4
1868-1868
2013