Sequence of PARG_HUMAN

poly(ADP-ribose) glycohydrolase

Q86W56

976

111110

1022677

Meyer R.G.,Meyer-Ficca M.L.,Jacobson E.L.,Jacobson M.K.

Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23).

Gene

314

181-190

2003

1022678

Meyer-Ficca M.L.,Meyer R.G.,Coyle D.L.,Jacobson E.L.,Jacobson M.K.

Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.

Exp. Cell Res.

297

521-532

2004

1022679

Ame J.-C.,Apiou F.,Jacobson E.L.,Jacobson M.K.

Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization.

Cytogenet. Cell Genet.

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1999

1022680

Meyer R.G.,Meyer-Ficca M.L.,Whatcott C.J.,Jacobson E.L.,Jacobson M.K.

Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity.

Exp. Cell Res.

313

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2007

1022681

Niere M.,Mashimo M.,Agledal L.,Dolle C.,Kasamatsu A.,Kato J.,Moss J.,Ziegler M.

ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

J. Biol. Chem.

287

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2012

1022682

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

1022683

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

1022684

Putt K.S.,Hergenrother P.J.

A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation.

Anal. Biochem.

333

256-264

2004

1022685

Haince J.F.,Ouellet M.E.,McDonald D.,Hendzel M.J.,Poirier G.G.

Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage.

Biochim. Biophys. Acta

1763

226-237

2006

1022686

Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

Nat. Biotechnol.

24

1285-1292

2006

1022687

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

1022688

Gagne J.P.,Moreel X.,Gagne P.,Labelle Y.,Droit A.,Chevalier-Pare M.,Bourassa S.,McDonald D.,Hendzel M.J.,Prigent C.,Poirier G.G.

Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase.

J. Proteome Res.

8

1014-1029

2009

1022689

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

RA46-RA46

2009

1022690

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

RA3-RA3

2010

1022691

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

1022692

Slade D.,Dunstan M.S.,Barkauskaite E.,Weston R.,Lafite P.,Dixon N.,Ahel M.,Leys D.,Ahel I.

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

Nature

477

616-620

2011

1022693

Mortusewicz O.,Fouquerel E.,Ame J.C.,Leonhardt H.,Schreiber V.

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.

Nucleic Acids Res.

39

5045-5056

2011

1022694

Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci. Signal.

4

RS3-RS3

2011

1022695

Le May N.,Iltis I.,Ame J.C.,Zhovmer A.,Biard D.,Egly J.M.,Schreiber V.,Coin F.

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

Mol. Cell

48

785-798

2012

1022696

Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Proc. Natl. Acad. Sci. U.S.A.

109

12449-12454

2012

1022697

Sharifi R.,Morra R.,Appel C.D.,Tallis M.,Chioza B.,Jankevicius G.,Simpson M.A.,Matic I.,Ozkan E.,Golia B.,Schellenberg M.J.,Weston R.,Williams J.G.,Rossi M.N.,Galehdari H.,Krahn J.,Wan A.,Trembath R.C.,Crosby A.H.,Ahel D.,Hay R.,Ladurner A.G.,Timinszky G.,Williams R.S.,Ahel I.

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.

EMBO J.

32

1225-1237

2013

1022698

Rosenthal F.,Feijs K.L.,Frugier E.,Bonalli M.,Forst A.H.,Imhof R.,Winkler H.C.,Fischer D.,Caflisch A.,Hassa P.O.,Luescher B.,Hottiger M.O.

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

Nat. Struct. Mol. Biol.

20

502-507

2013

1022699

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

1022700

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

1022701

Illuzzi G.,Fouquerel E.,Ame J.C.,Noll A.,Rehmet K.,Nasheuer H.P.,Dantzer F.,Schreiber V.

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.

Nucleic Acids Res.

42

7776-7792

2014

1022702

Wright R.H.,Lioutas A.,Le Dily F.,Soronellas D.,Pohl A.,Bonet J.,Nacht A.S.,Samino S.,Font-Mateu J.,Vicent G.P.,Wierer M.,Trabado M.A.,Schelhorn C.,Carolis C.,Macias M.J.,Yanes O.,Oliva B.,Beato M.

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

Science

352

1221-1225

2016

1022703

Bonfiglio J.J.,Leidecker O.,Dauben H.,Longarini E.J.,Colby T.,San Segundo-Acosta P.,Perez K.A.,Matic I.

An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation.

Cell

183

1086-1102

2020

1022704

Prokhorova E.,Agnew T.,Wondisford A.R.,Tellier M.,Kaminski N.,Beijer D.,Holder J.,Groslambert J.,Suskiewicz M.J.,Zhu K.,Reber J.M.,Krassnig S.C.,Palazzo L.,Murphy S.,Nielsen M.L.,Mangerich A.,Ahel D.,Baets J.,O'Sullivan R.J.,Ahel I.

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.

Mol. Cell

81

2640-2655.e8

2021

1022705

Rack J.G.M.,Liu Q.,Zorzini V.,Voorneveld J.,Ariza A.,Honarmand Ebrahimi K.,Reber J.M.,Krassnig S.C.,Ahel D.,van der Marel G.A.,Mangerich A.,McCullagh J.S.O.,Filippov D.V.,Ahel I.

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.

Nat. Commun.

12

4581-4581

2021

1022706

Tucker J.A.,Bennett N.,Brassington C.,Durant S.T.,Hassall G.,Holdgate G.,McAlister M.,Nissink J.W.,Truman C.,Watson M.

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.

PLoS ONE

7

E50889-E50889

2012

1022707

Rack J.G.M.,Ariza A.,Drown B.S.,Henfrey C.,Bartlett E.,Shirai T.,Hergenrother P.J.,Ahel I.

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

Cell Chem. Biol.

0

0-0

2018