Sequence of MEP1B_MOUSE
EC Number:3.4.24.63
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-/-Leu-, -Leu6-/-Cys-, -Ala14-/-Leu- and -Cys19-/-Gly- bonds in insulin B chain
General information:
Sequence
0 MDARHQPWFL VFATFLLVSG LPAPEKFVKD IDGGIDQDIF DINQGLGLDL FEGDIKLEAN
60 GKNSIIGDHK RWPHTIPYVL EDSLEMNAKG VILNAFERYR LKTCIDFKPW SGEANYISVF
120 KGSGCWSSVG NIHAGKQELS IGTNCDRIAT VQHEFLHALG FWHEQSRADR DDYVIIVWDR
180 IQPGKEHNFN IYNDSVSDSL NVPYDYTSVM HYSKTAFQNG TESTIVTRIS EFEDVIGQRM
240 DFSDYDLLKL NQLYNCTSSL SFMDSCDFEL ENICGMIQSS GDSADWQRVS QVLSGPESDH
300 SKMGQCKDSG FFMHFNTSIL NEGATAMLES RLLYPKRGFQ CLEFYLYNSG SGNDQLNIYT
360 REYTTGQQGG VLTLQRQIKE VPIGSWQLHY VTLQVTKKFR VVFEGLRGPG TSSGGLSIDD
420 INLSETRCPH HIWHIQNFTQ ILGGQDTSVY SPPFYSSKGY AFQIYMDLRS STNVGIYFHL
480 ISGANDDQLQ WPCPWQQATM TLLDQNPDIR QRMFNQRSIT TDPTMTSDNG SYFWDRPSKV
540 GVTDVFPNGT QFSRGIGYGT TVFITRERLK SREFIKGDDI YILLTVEDIS HLNSTSAVPD
600 PVPTLAVHNA CSEVVCQNGG ICVVQDGRAE CKCPAGEDWW YMGKRCEKRG STRDTVIIAV
660 SSTVTVFAVM LIITLVSVYC TRRKYRKKAR ANTAAMTLEN QHAF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
915513
Gorbea C.M.,Marchand P.,Jiang W.,Copeland N.G.,Gilbert D.J.,Jenkins N.A.,Bond J.S.
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
J. Biol. Chem.
268
21035-21043
1993
915514
Dietrich J.M.,Bond J.S.,Jiang W.
A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells.
J. Biol. Chem.
271
2271-2278
1996
915516
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
915517
Kounnas M.Z.,Wolz R.L.,Gorbea C.M.,Bond J.S.
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
J. Biol. Chem.
266
17350-17357
1991
915518
Gorbea C.M.,Flannery A.V.,Bond J.S.
Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B.
Arch. Biochem. Biophys.
290
549-553
1991
915519
Bertenshaw G.P.,Turk B.E.,Hubbard S.J.,Matters G.L.,Bylander J.E.,Crisman J.M.,Cantley L.C.,Bond J.S.
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
J. Biol. Chem.
276
13248-13255
2001
915520
Hirano M.,Ma B.Y.,Kawasaki N.,Okimura K.,Baba M.,Nakagawa T.,Miwa K.,Kawasaki N.,Oka S.,Kawasaki T.
Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta.
J. Immunol.
175
3177-3185
2005
915521
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
