Sequence of Q27GR1_ACTS5

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
galactosylceramidase
Q27GR1
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
785
82815
Reaction
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MRHLLMVAVT AAAIGTLAAP APAAAATTVA LNGGIVGRAF DGVGAISGGG GNSRLLIDYP
 60 EPQRGQILDY LFKPGYGAAV QLLKLEIGGD ANSTDGSEPS HQHVRGDINC NAGYEFWLGE
120 QAVARNPGIR LVALPWAAPG WIGGGSFWST DMINYDVSWL NCARQYGLTI SYLGGWNERG
180 HDSTWYKNLR TGLDNAGYSA VQIVGDDSGW GMADEFAADP TLKNAVGVLG NHYVCGYLSQ
240 ADSCSTTGNA RSSGKPLWAS EFGSQDDNAG VVPYIRTVNR GYLDAEISGY MNWPLIAAIT
300 PNLPFATVGL MDAGSPWSGA YRVGRNLWAN AHYAQFTQPG WHYLNSSASG YLGGNRANGS
360 YVTLKSTNNT DYSTIYETSG STAAQTVNVT VSGGLSTGTV HVWSTDMGSS NSADWFVRQA
420 DITPVGATYT LNLQPNRIYT VTTTTGQGKG TAAGPAPHGL ALPYSDNFDG YAVRKLPHYS
480 EDMQGSFETR ACSAGRGGTC LQQVAPLRPI NWQDDSDAFT LFGDTGWTNY TVSLDVNMQQ
540 AGTVTLLGRA NIQNRPQNRQ AAYQLRVTDN GGWSIVKHTN ADTDTTLVSG TRAALGLNSW
600 HNLRLGFSGG QITAAIDNTT VGTVTDYAYG AGQAGVGVVG YQTDQFDNLS VTPNSGPALN
660 TLRGVESGRC ADVPGASQTN GTQLALWDCN GGSNQNFTLT DQKQLLVYGS KCLDVNAGGT
720 ADGAKVQIWD CHGGTNQQWT LNADGTIVGI GSGKCLDATG HGTANGTLLE IWTCNGGDNQ
780 KWSRS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
16051423
Stratmann A.,Mahmud T.,Lee S.,Distler J.,Floss H.G.,Piepersberg W.
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
J. Biol. Chem.
274
10889-10896
1999
16051425
Hemker M.,Stratmann A.,Goeke K.,Schroeder W.,Lenz J.,Piepersberg W.,Pape H.
Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50.
J. Bacteriol.
183
4484-4492
2001
16051426
Zhang C.,Stratmann A.,Block O.,Brueckner R.,Podeschwa M.,Altenbach H.J.,Wehmeier U.F.,Piepersberg W.
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
J. Biol. Chem.
277
22853-22862
2002
16051427
Zhang C.,Podeschwa M.,Altenbach H.J.,Piepersberg W.,Wehmeier U.F.
The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.
FEBS Lett.
540
47-52
2003
16051428
Brunkhorst C.,Wehmeier U.F.,Piepersberg W.,Schneider E.
The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs.
Res. Microbiol.
156
322-327
2005