Sequence of POLG_MVEV5
EC Number:3.4.21.91
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Selective hydrolysis of -Xaa-Xaa-/-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala
Other sequences found for EC No. 3.4.21.91
General information:
Sequence
0 MSKKPGGPGK PRVVNMLKRG IPRVFPLVGV KRVVMNLLDG RGPIRFVLAL LAFFRFTALA
60 PTKALMRRWK SVNKTTAMKH LTSFKKELGT LIDVVNKRGK KQKKRGGSET SVLMLIFMLI
120 GFAAALKLST FQGKIMMTVN ATDIADVIAI PTPKGPNQCW IRAIDIGFMC DDTITYECPK
180 LESGNDPEDI DCWCDKQAVY VNYGRCTRAR HSKRSRRSIT VQTHGESTLV NKKDAWLDST
240 KATRYLTKTE NWIIRNPGYA LVAVVLGWML GSNTGQKVIF TVLLLLVAPA YSFNCLGMSS
300 RDFIEGASGA TWVDLVLEGD SCITIMAADK PTLDIRMMNI EATNLALVRN YCYAATVSDV
360 STVSNCPTTG ESHNTKRADH NYLCKRGVTD RGWGNGCGLF GKGSIDTCAK FTCSNSAAGR
420 LILPEDIKYE VGVFVHGSTD STSHGNYSTQ IGANQAVRFT ISPNAPAITA KMGDYGEVTV
480 ECEPRSGLNT EAYYVMTIGT KHFLVHREWF NDLLLPWTSP ASTEWRNREI LVEFEEPHAT
540 KQSVVALGSQ EGALHQALAG AIPVEFSSST LKLTSGHLKC RVKMEKLKLK GTTYGMCTEK
600 FTFSKNPADT GHGTVVLELQ YTGSDGPCKI PISSVASLND MTPVGRMVTA NPYVASSTAN
660 AKVLVEIEPP FGDSYIVVGR GDKQINHHWH KEGSSIGKAF STTLKGAQRL AALGDTAWDF
720 GSVGGVFNSI GKAVHQVFGG AFRTLFGGMS WISPGLLGAL LLWMGVNARD KSIALAFLAT
780 GGVLLFLATN VHADTGCAID ITRRELKCGS GIFIHNDVEA WIDRYKYLPE TPKQLAKVVE
840 NAHKSGICGI RSVNRFEHQM WESVRDELNA LLKENAIDLS VVVEKQKGMY RAAPNRLRLT
900 VEELDIGWKA WGKSLLFAAE LANSTFVVDG PETAECPNSK RAWNSFEIED FGFGITSTRG
960 WLKLREENTS ECDSTIIGTA VKGNHAVHSD LSYWIESGLN GTWKLERAIF GEVKSCTWPE
1020 THTLWGDAVE ETELIIPVTL AGPRSKHNRR EGYKVQVQGP WDEEDIKLDF DYCPGTTVTV
1080 SEHCGKRGPS VRTTTDSGKL VTDWCCRSCT LPPLRFTTAS GCWYGMEIRP MKHDESTLVK
1140 SRVQAFNGDM IDPFQLGLLV MFLATQEVLR KRWTARLTLP AAVGALLVLL LGGITYTDLV
1200 RYLILVGSAF AESNNGGDVI HLALIAVFKV QPAFLVASLT RSRWTNQENL VLVLGAAFFQ
1260 MAASDLELTI PGLLNSAATA WMVLRAMAFP STSAIAMPML AMLAPGMRML HLDTYRIVLL
1320 LIGICSLLNE RRRSVEKKKG AVLIGLALTS TGYFSPTIMA AGLMICNPNK KRGWPATEVL
1380 TAVGLMFAIV GGLAELDIDS MSVPFTIAGL MLVSYVISGK ATDMWLERAA DVSWEAGAAI
1440 TGTSERLDVQ LDDDGDFHLL NDPGVPWKIW VLRMTCLSVA AITPRAILPS AFGYWLTLKY
1500 TKRGGVFWDT PSPKVYPKGD TTPGVYRIMA RGILGRYQAG VGVMHEGVFH TLWHTTRGAA
1560 IMSGEGRLTP YWGNVKEDRV TYGGPWKLDQ KWNGVDDVQM IVVEPGKPAI NVQTKPGIFK
1620 TAHGEIGAVS LDYPIGTSGS PIVNSNGEII GLYGNGVILG NGAYVSAIVQ GERVEEPVPE
1680 AYNPEMLKKR QLTVLDLHPG AGKTRRILPQ IIKDAIQKRL RTAVLAPTRV VAAEMAEALR
1740 GLPVRYLTPA VQREHSGNEI VDVMCHATLT HRLMSPLRVP NYNLFVMDEA HFTDPASIAA
1800 RGYIATRVEA GEAAAIFMTA TPPGTSDPFP DTNSPVHDVS SEIPDRAWSS GFEWITDYAG
1860 KTVWFVASVK MSNEIAQCLQ RAGKRVIQLN RKSYDTEYPK CKNGDWDFVI TTDISEMGAN
1920 FGASRVIDCR KSVKPTILDE GEGRVILSVP SAITSASAAQ RRGRVGRNPS QIGDEYHYGG
1980 GTSEDDTMLA HWTEAKILLD NIHLPNGLVA QLYGPERDKT YTMDGEYRLR GEERKTFLEL
2040 IKTADLPVWL AYKVASNGIQ YNDRKWCFDG PRSNIILEDN NEVEIITRIG ERKVLKPRWL
2100 DARVYSDHQS LKWFKDFAAG KRSAIGFFEV LGRMPEHFAG KTREALDTMY LVATSEKGGK
2160 AHRMALEELP DALETITLIA ALGVMTAGFF LLMMQRKGIG KLGLGALVLV VATFFLWMSD
2220 VSGTKIAGVL LLALLMMVVL IPEPEKQRSQ TDNQLAVFLI CVLLVVGLVA ANEYGMLERT
2280 KTDIRNLFGK SLIEENEVHI PPFDFFTLDL KPATAWALYG GSTVVLTPLI KHLVTSQYVT
2340 TSLASINAQA GSLFTLPKGI PFTDFDLSVA LVFLGCWGQV TLTTLIMATI LVTLHYGYLL
2400 PGWQAEALRA AQKRTAAGIM KNAVVDGIVA TDVPELERTT PQMQKRLGQI LLVLASVAAV
2460 CVNPRITTIR EAGILCTAAA LTLWDNNASA AWNSTTATGL CHVMRGSWIA GASIAWTLIK
2520 NAEKPAFKRG RAGGRTLGEQ WKEKLNAMGK EEFFSYRKEA ILEVDRTEAR RARREGNKVG
2580 GHPVSRGTAK LRWLVERRFV QPIGKVVDLG CGRGGWSYYA ATMKNVQEVR GYTKGGPGHE
2640 EPMLMQSYGW NIVTMKSGVD VFYKPSEISD TLLCDIGESS PSAEIEEQRT LRILEMVSDW
2700 LSRGPKEFCI KILCPYMPKV IEKLESLQRR FGGGLVRVPL SRNSNHEMYW VSGASGNIVH
2760 AVNMTSQVLI GRMDKKIWKG PKYEEDVNLG SGTRAVGKGV QHTDYKRIKS RIEKLKEEYA
2820 ATWHTDDNHP YRTWTYHGSY EVKPSGSAST LVNGVVRLLS KPWDAITGVT TMAMTDTTPF
2880 GQQRVFKEKV DTKAPEPPQG VKTVMDETTN WLWAYLARNK KARLCTREEF VKKVNSHAAL
2940 GAMFEEQNQW KNAREAVEDP KFWEMVDEER ECHLRGECRT CIYNMMGKRE KKPGEFGKAK
3000 GSRAIWFMWL GARFLEFEAL GFLNEDHWMS RENSGGGVEG AGIQKLGYIL RDVAQKPGGK
3060 IYADDTAGWD TRITQADLEN EAKVLELMEG EQRTLARAII ELTYRHKVVK VMRPAAGGKT
3120 VMDVISREDQ RGSGQVVTYA LNTFTNIAVQ LVRLMEAEAV IGPDDIESIE RKKKFAVRTW
3180 LFENAEERVQ RMAVSGDDCV VKPLDDRFST ALHFLNAMSK VRKDIQEWKP SQGWYDWQQV
3240 PFCSNHFQEV IMKDGRTLVV PCRGQDELIG RARISPGSGW NVRDTACLAK AYAQMWLVLY
3300 FHRRDLRLMA NAICSSVPVD WVPTGRTTWS IHGKGEWMTT EDMLSVWNRV WILENEWMED
3360 KTTVSDWTEV PYVGKREDIW CGSLIGTRTR ATWAENIYAA INQVRSVIGK EKYVDYVQSL
3420 RRYEETHVSE DRVL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
76855
Hurrelbrink R.J.,Nestorowicz A.,McMinn P.C.
Characterization of infectious Murray Valley encephalitis virus derived from a stably cloned genomic-length cDNA.
J. Gen. Virol.
80
3115-3125
1999
76856
Dalgarno L.,Trent D.W.,Strauss J.H.,Rice C.M.
Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins.
J. Mol. Biol.
187
309-323
1986
76857
Lee E.,Fernon C.,Simpson R.,Weir R.C.,Rice C.M.,Dalgarno L.
Sequence of the 3' half of the Murray Valley encephalitis virus genome and mapping of the nonstructural proteins NS1, NS3, and NS5.
Virus Genes
4
197-213
1990
76858
Winkler G.,Heinz F.X.,Kunz C.
Studies on the glycosylation of flavivirus E proteins and the role of carbohydrate in antigenic structure.
Virology
159
237-243
1987
76859
Lobigs M.
Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3.
Proc. Natl. Acad. Sci. U.S.A.
90
6218-6222
1993
76860
Stocks C.E.,Lobigs M.
Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM.
J. Virol.
72
2141-2149
1998
76861
Stocks C.E.,Lobigs M.
Posttranslational signal peptidase cleavage at the flavivirus C-prM junction in vitro.
J. Virol.
69
8123-8126
1995
76862
Blitvich B.J.,Scanlon D.,Shiell B.J.,Mackenzie J.S.,Pham K.,Hall R.A.
Determination of the intramolecular disulfide bond arrangement and biochemical identification of the glycosylation sites of the nonstructural protein NS1 of Murray Valley encephalitis virus.
J. Gen. Virol.
82
2251-2256
2001
76863
Lobigs M.,Lee E.,Ng M.L.,Pavy M.,Lobigs P.
A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis.
Virology
401
80-89
2010
76864
Addis S.N.,Lee E.,Bettadapura J.,Lobigs M.
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction.
Virol. J.
12
144-144
2015
76865
Mancini E.J.,Assenberg R.,Verma A.,Walter T.S.,Tuma R.,Grimes J.M.,Owens R.J.,Stuart D.I.
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.
Protein Sci.
16
2294-2300
2007
76866
Assenberg R.,Ren J.,Verma A.,Walter T.S.,Alderton D.,Hurrelbrink R.J.,Fuller S.D.,Bressanelli S.,Owens R.J.,Stuart D.I.,Grimes J.M.
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J. Gen. Virol.
88
2228-2236
2007
76867
Assenberg R.,Mastrangelo E.,Walter T.S.,Verma A.,Milani M.,Owens R.J.,Stuart D.I.,Grimes J.M.,Mancini E.J.
Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication.
J. Virol.
83
12895-12906
2009
