Sequence of FAK1_CHICK
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MAAAYLDPNL NHTPSSSAKT HLGTGMERSP GAMERVLKVF HYFENSSEPT TWASIIRHGD
60 ATDVRGIIQK IVDCHKVKNV ACYGLRLSHL QSEEVHWLHL DMGVSNVREK FELAHPPEEW
120 KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKNDYMLEIA DQVDQEIALK LGCLEIRRSY
180 GEMRGNALEK KSNYEVLEKD VGLRRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI
240 LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGANP THLADFNQVQ
300 TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGATQSFII
360 RPQKEGERAL PSIPKLANNE KQGVRSHTVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE
420 RIELGRCIGE GQFGDVHQGI YMSPENPAMA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH
480 PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKFSLDL ASLILYAYQL STALAYLESK
540 RFVHRDIAAR NVLVSATDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT
600 SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA
660 YDPSRRPRFT ELKAQLSTIL EEEKLQQEER MRMESRRQVT VSWDSGGSDE APPKPSRPGY
720 PSPRSSEGFY PSPQHMVQPN HYQVSGYSGS HGIPAMAGSI YPGQASLLDQ TDSWNHRPQE
780 VSAWQPNMED SGTLDVRGMG QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLVMKPDVR
840 LSRGSIERED GGLQGPAGNQ HIYQPVGKPD HAAPPKKPPR PGAPHLGSLA SLNSPVDSYN
900 EGVKIKPQEI SPPPTANLDR SNDKVYENVT GLVKAVIEMS SKIQPAPPEE YVPMVKEVGL
960 ALRTLLATVD ESLPVLPAST HREIEMAQKL LNSDLAELIN KMKLAQQYVM TSLQQEYKKQ
1020 MLTAAHALAV DAKNLLDVID QARLKMISQS RPH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
797374
Schaller M.D.,Borgman C.A.,Cobb B.S.,Vines R.R.,Reynolds A.B.,Parsons J.T.
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
Proc. Natl. Acad. Sci. U.S.A.
89
5192-5196
1992
797375
Devor B.B.,Zhang X.,Patel S.K.,Polte T.R.,Hanks S.K.
Chicken and mouse focal adhesion kinases are similar in structure at their amino termini.
Biochem. Biophys. Res. Commun.
190
1084-1089
1993
797376
Schaller M.D.,Borgman C.A.,Parsons J.T.
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
Mol. Cell. Biol.
13
785-791
1993
797377
Hildebrand J.D.,Taylor J.M.,Parsons J.T.
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.
Mol. Cell. Biol.
16
3169-3178
1996
797378
Reiske H.R.,Kao S.C.,Cary L.A.,Guan J.L.,Lai J.F.,Chen H.C.
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration.
J. Biol. Chem.
274
12361-12366
1999
797379
Shen T.L.,Han D.C.,Guan J.L.
Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.
J. Biol. Chem.
277
29069-29077
2002
797380
Leu T.H.,Maa M.C.
Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.
Oncogene
21
6992-7000
2002
797381
Ren X.R.,Ming G.L.,Xie Y.,Hong Y.,Sun D.M.,Zhao Z.Q.,Feng Z.,Wang Q.,Shim S.,Chen Z.F.,Song H.J.,Mei L.,Xiong W.C.
Focal adhesion kinase in netrin-1 signaling.
Nat. Neurosci.
7
1204-1212
2004
797382
Li W.,Lee J.,Vikis H.G.,Lee S.H.,Liu G.,Aurandt J.,Shen T.L.,Fearon E.R.,Guan J.L.,Han M.,Rao Y.,Hong K.,Guan K.L.
Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Nat. Neurosci.
7
1213-1221
2004
797383
Liu G.,Beggs H.,Jurgensen C.,Park H.T.,Tang H.,Gorski J.,Jones K.R.,Reichardt L.F.,Wu J.,Rao Y.
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.
Nat. Neurosci.
7
1222-1232
2004
797384
Serrels B.,Serrels A.,Brunton V.G.,Holt M.,McLean G.W.,Gray C.H.,Jones G.E.,Frame M.C.
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.
Nat. Cell Biol.
9
1046-1056
2007
797385
Koshman Y.E.,Kim T.,Chu M.,Engman S.J.,Iyengar R.,Robia S.L.,Samarel A.M.
FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells.
Arterioscler. Thromb. Vasc. Biol.
30
2226-2233
2010
797386
Koshman Y.E.,Chu M.,Engman S.J.,Kim T.,Iyengar R.,Robia S.L.,Samarel A.M.
Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130Cas Binding.
Arterioscler. Thromb. Vasc. Biol.
31
2432-2440
2011
797387
Chu M.,Iyengar R.,Koshman Y.E.,Kim T.,Russell B.,Martin J.L.,Heroux A.L.,Robia S.L.,Samarel A.M.
Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy.
Cardiovasc. Res.
92
409-419
2011
797388
Liu G.,Guibao C.D.,Zheng J.
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase.
Mol. Cell. Biol.
22
2751-2760
2002
797389
Gao G.,Prutzman K.C.,King M.L.,Scheswohl D.M.,DeRose E.F.,London R.E.,Schaller M.D.,Campbell S.L.
NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model.
J. Biol. Chem.
279
8441-8451
2004
797390
Prutzman K.C.,Gao G.,King M.L.,Iyer V.V.,Mueller G.A.,Schaller M.D.,Campbell S.L.
The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation.
Structure
12
881-891
2004
797391
Ceccarelli D.F.,Song H.K.,Poy F.,Schaller M.D.,Eck M.J.
Crystal structure of the FERM domain of focal adhesion kinase.
J. Biol. Chem.
281
252-259
2006
797392
Lietha D.,Cai X.,Ceccarelli D.F.,Li Y.,Schaller M.D.,Eck M.J.
Structural basis for the autoinhibition of focal adhesion kinase.
Cell
129
1177-1187
2007
797393
Lietha D.,Eck M.J.
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.
PLoS ONE
3
0-0
2008
