Sequence of NEIL3_MOUSE
EC Number:4.2.99.18
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Other sequences found for EC No. 4.2.99.18
General information:
Sequence
0 MVEGPGCTLN GEKIRARVLP GQAVTGVRGT ALQSLLGPAM SPAASLADVA TSAAPMNAKD
60 SGWKLLRLFN GYVYSGVETL GKELFMYFGP RALRIHFGMK GSILINPREG ENRAGASPAL
120 AVQLTRDLIC FYDSSVELRN SVESQQRVRV MEELDICSPK FSFSRAESEV KKQGDRMLCD
180 VLLDQRVLPG VGNIIKNEAL FDSGLHPAVK VCQLSDKQAC HLVKMTRDFS ILFYRCCKAG
240 SAISKHCKVY KRPNCDQCHS KITVCRFGEN SRMTYFCPHC QKENPQCVQV CQLPTRNTEI
300 SWTPRGEDCF TDSVARKSEE QWSCVVCTLI NRPSAKACDA CLTTRPLDSV LKNRENSIAF
360 NNLVKYPCNN FENTHTEVKI NRKTAFGNTT LVLTDLSNKS SALARKKRAN HTIDGESQMF
420 LPTDIGFSDS QHPSKEGINY ITQPSNKVNI SPTVCAQSKL FSSAHKKFKP AHTSATELKS
480 YNSGLSNSEL QTNRTRGHHS KSDGSPLCKM HHRRCVLRVV RKDGENKGRQ FYACSLPRGA
540 QCGFFEWADL SFPFCRHGKR SIMKTVLKIG PNNGKNFFVC PLEKKKQCNF FQWAENGPGM
600 EIVPGC
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
65474
Torisu K.,Tsuchimoto D.,Ohnishi Y.,Nakabeppu Y.
Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.
J. Biochem.
138
763-772
2005
65475
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
65476
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
65478
Liu M.,Bandaru V.,Holmes A.,Averill A.M.,Cannan W.,Wallace S.S.
Expression and purification of active mouse and human NEIL3 proteins.
Protein Expr. Purif.
84
130-139
2012
65479
Liu M.,Bandaru V.,Bond J.P.,Jaruga P.,Zhao X.,Christov P.P.,Burrows C.J.,Rizzo C.J.,Dizdaroglu M.,Wallace S.S.
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
Proc. Natl. Acad. Sci. U.S.A.
107
4925-4930
2010
65480
Hildrestrand G.A.,Neurauter C.G.,Diep D.B.,Castellanos C.G.,Krauss S.,Bjoras M.,Luna L.
Expression patterns of Neil3 during embryonic brain development and neoplasia.
BMC Neurosci.
10
45-45
2009
65481
Takao M.,Oohata Y.,Kitadokoro K.,Kobayashi K.,Iwai S.,Yasui A.,Yonei S.,Zhang Q.M.
Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.
Genes Cells
14
261-270
2009
65482
Sejersted Y.,Hildrestrand G.A.,Kunke D.,Rolseth V.,Krokeide S.Z.,Neurauter C.G.,Suganthan R.,Atneosen-Asegg M.,Fleming A.M.,Saugstad O.D.,Burrows C.J.,Luna L.,Bjoras M.
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Proc. Natl. Acad. Sci. U.S.A.
108
18802-18807
2011
65483
Regnell C.E.,Hildrestrand G.A.,Sejersted Y.,Medin T.,Moldestad O.,Rolseth V.,Krokeide S.Z.,Suganthan R.,Luna L.,Bjoras M.,Bergersen L.H.
Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.
Cell Rep.
2
503-510
2012
65484
Rolseth V.,Krokeide S.Z.,Kunke D.,Neurauter C.G.,Suganthan R.,Sejersted Y.,Hildrestrand G.A.,Bjoras M.,Luna L.
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.
Biochim. Biophys. Acta
1833
1157-1164
2013
65485
Liu M.,Imamura K.,Averill A.M.,Wallace S.S.,Doublie S.
Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA.
Structure
21
247-256
2013
