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Sequence of DNAS1_HUMAN

EC Number:3.1.21.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
deoxyribonuclease I
P24855
Homo sapiens
282
31434
Reaction
endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products

General information:

Sequence
show sequence in fasta format
  0 MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI LSRYDIALVQ
 60 EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE RYLFVYRPDQ VSAVDSYYYD
120 DGCEPCGNDT FNREPAIVRF FSRFTEVREF AIVPLHAAPG DAVAEIDALY DVYLDVQEKW
180 GLEDVMLMGD FNAGCSYVRP SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG
240 MLLRGAVVPD SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
471845
Shak S.,Capon D.J.,Hellmiss R.,Marsters S.A.,Baker C.L.
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.
Proc. Natl. Acad. Sci. U.S.A.
87
9188-9192
1990
471846
Yasuda T.,Kishi K.,Yanagawa Y.,Yoshida A.
Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism.
Ann. Hum. Genet.
59
1-15
1995
471847
Oliveri M.,Daga A.,Cantoni C.,Lunardi C.,Millo R.,Puccetti A.
DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis.
Eur. J. Immunol.
31
743-751
2001
471848
Kominato Y.,Ueki M.,Iida R.,Kawai Y.,Nakajima T.,Makita C.,Itoi M.,Tajima Y.,Kishi K.,Yasuda T.
Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation.
FEBS J.
273
3094-3105
2006
471849
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
471850
Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.
The sequence and analysis of duplication-rich human chromosome 16.
Nature
432
988-994
2004
471852
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
471853
Rosenstreich D.L.,Tu J.H.,Kinkade P.R.,Maurer-Fogy I.,Kahn J.,Barton R.W.,Farina P.R.
A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I.
J. Exp. Med.
168
1767-1779
1988
471854
Yasuda T.,Awazu S.,Sato W.,Iida R.,Tanaka Y.,Kishi K.
Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I.
J. Biochem.
108
393-398
1990
471855
Yasutomo K.,Horiuchi T.,Kagami S.,Tsukamoto H.,Hashimura C.,Urushihara M.,Kuroda Y.
Mutation of DNASE1 in people with systemic lupus erythematosus.
Nat. Genet.
28
313-314
2001
471856
Hakkim A.,Fuernrohr B.G.,Amann K.,Laube B.,Abed U.A.,Brinkmann V.,Herrmann M.,Voll R.E.,Zychlinsky A.
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.
Proc. Natl. Acad. Sci. U.S.A.
107
9813-9818
2010
471857
Yasuda T.,Nadano D.,Takeshita H.,Tenjo E.,Kishi K.
Molecular analysis of the third allele of human deoxyribonuclease I polymorphism.
Ann. Hum. Genet.
59
139-147
1995
471858
Yasuda T.,Nadano D.,Takeshita H.,Tenjo E.,Sawazaki K.,Ootani M.,Kishi K.
The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele.
FEBS Lett.
359
211-214
1995
471859
Iida R.,Yasuda T.,Aoyama M.,Tsubota E.,Kobayashi M.,Yuasa I.,Matsuki T.,Kishi K.
The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism.
Electrophoresis
18
1936-1939
1997
471860
Yasuda T.,Takeshita H.,Iida R.,Kogure S.,Kishi K.
A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability.
Biochem. Biophys. Res. Commun.
260
280-283
1999