Sequence of UBA1_YEAST
EC Number:6.2.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
E1 ubiquitin-activating enzyme
P22515
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1024
114266
Reaction
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
General information:
Sequence
0 MSSNNSGLSA AGEIDESLYS RQLYVLGKEA MLKMQTSNVL ILGLKGLGVE IAKNVVLAGV
60 KSMTVFDPEP VQLADLSTQF FLTEKDIGQK RGDVTRAKLA ELNAYVPVNV LDSLDDVTQL
120 SQFQVVVATD TVSLEDKVKI NEFCHSSGIR FISSETRGLF GNTFVDLGDE FTVLDPTGEE
180 PRTGMVSDIE PDGTVTMLDD NRHGLEDGNF VRFSEVEGLD KLNDGTLFKV EVLGPFAFRI
240 GSVKEYGEYK KGGIFTEVKV PRKISFKSLK QQLSNPEFVF SDFAKFDRAA QLHLGFQALH
300 QFAVRHNGEL PRTMNDEDAN ELIKLVTDLS VQQPEVLGEG VDVNEDLIKE LSYQARGDIP
360 GVVAFFGGLV AQEVLKACSG KFTPLKQFMY FDSLESLPDP KNFPRNEKTT QPVNSRYDNQ
420 IAVFGLDFQK KIANSKVFLV GSGAIGCEML KNWALLGLGS GSDGYIVVTD NDSIEKSNLN
480 RQFLFRPKDV GKNKSEVAAE AVCAMNPDLK GKINAKIDKV GPETEEIFND SFWESLDFVT
540 NALDNVDART YVDRRCVFYR KPLLESGTLG TKGNTQVIIP RLTESYSSSR DPPEKSIPLC
600 TLRSFPNKID HTIAWAKSLF QGYFTDSAEN VNMYLTQPNF VEQTLKQSGD VKGVLESISD
660 SLSSKPHNFE DCIKWARLEF EKKFNHDIKQ LLFNFPKDAK TSNGEPFWSG AKRAPTPLEF
720 DIYNNDHFHF VVAGASLRAY NYGIKSDDSN SKPNVDEYKS VIDHMIIPEF TPNANLKIQV
780 NDDDPDPNAN AANGSDEIDQ LVSSLPDPST LAGFKLEPVD FEKDDDTNHH IEFITACSNC
840 RAQNYFIETA DRQKTKFIAG RIIPAIATTT SLVTGLVNLE LYKLIDNKTD IEQYKNGFVN
900 LALPFFGFSE PIASPKGEYN NKKYDKIWDR FDIKGDIKLS DLIEHFEKDE GLEITMLSYG
960 VSLLYASFFP PKKLKERLNL PITQLVKLVT KKDIPAHVST MILEICADDK EGEDVEVPFI
1020 TIHL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
462536
McGrath J.P.,Jentsch S.,Varshavsky A.
UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.
EMBO J.
10
227-236
1991
462537
Dujon B.,Alexandraki D.,Andre B.,Ansorge W.,Baladron V.,Ballesta J.P.G.,Banrevi A.,Bolle P.-A.,Bolotin-Fukuhara M.,Bossier P.,Bou G.,Boyer J.,Buitrago M.J.,Cheret G.,Colleaux L.,Daignan-Fornier B.,del Rey F.,Dion C.,Domdey H.,Duesterhoeft A.,Duesterhus S.,Entian K.-D.,Erfle H.,Esteban P.F.,Feldmann H.,Fernandes L.,Fobo G.M.,Fritz C.,Fukuhara H.,Gabel C.,Gaillon L.,Garcia-Cantalejo J.M.,Garcia-Ramirez J.J.,Gent M.E.,Ghazvini M.,Goffeau A.,Gonzalez A.,Grothues D.,Guerreiro P.,Hegemann J.H.,Hewitt N.,Hilger F.,Hollenberg C.P.,Horaitis O.,Indge K.J.,Jacquier A.,James C.M.,Jauniaux J.-C.,Jimenez A.,Keuchel H.,Kirchrath L.,Kleine K.,Koetter P.,Legrain P.,Liebl S.,Louis E.J.,Maia e Silva A.,Marck C.,Monnier A.-L.,Moestl D.,Mueller S.,Obermaier B.,Oliver S.G.,Pallier C.,Pascolo S.,Pfeiffer F.,Philippsen P.,Planta R.J.,Pohl F.M.,Pohl T.M.,Poehlmann R.,Portetelle D.,Purnelle B.,Puzos V.,Ramezani Rad M.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Richard G.-F.,Rieger M.,Rodrigues-Pousada C.,Rose M.,Rupp T.,Santos M.A.,Schwager C.,Sensen C.,Skala J.,Soares H.,Sor F.,Stegemann J.,Tettelin H.,Thierry A.,Tzermia M.,Urrestarazu L.A.,van Dyck L.,van Vliet-Reedijk J.C.,Valens M.,Vandenbol M.,Vilela C.,Vissers S.,von Wettstein D.,Voss H.,Wiemann S.,Xu G.,Zimmermann J.,Haasemann M.,Becker I.,Mewes H.-W.
Complete DNA sequence of yeast chromosome XI.
Nature
369
371-378
1994
462538
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
462539
McGrath J.P.,Varshavsky A.
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein.
Nature
340
400-404
1989
462540
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
462541
Chi A.,Huttenhower C.,Geer L.Y.,Coon J.J.,Syka J.E.P.,Bai D.L.,Shabanowitz J.,Burke D.J.,Troyanskaya O.G.,Hunt D.F.
Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Proc. Natl. Acad. Sci. U.S.A.
104
2193-2198
2007
462542
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
462543
Harreman M.,Taschner M.,Sigurdsson S.,Anindya R.,Reid J.,Somesh B.,Kong S.E.,Banks C.A.,Conaway R.C.,Conaway J.W.,Svejstrup J.Q.
Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.
Proc. Natl. Acad. Sci. U.S.A.
106
20705-20710
2009
462544
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
462545
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
462546
Starita L.M.,Lo R.S.,Eng J.K.,von Haller P.D.,Fields S.
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Proteomics
12
236-240
2012
462547
Lee I.,Schindelin H.
Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.
Cell
134
268-278
2008
462548
Schafer A.,Kuhn M.,Schindelin H.
Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules.
Acta Crystallogr. D
70
1311-1320
2014
462549
Truongvan N.,Li S.,Misra M.,Kuhn M.,Schindelin H.
Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
Nat. Commun.
13
4789-4789
2022
