Sequence of CARP2_CANAX
EC Number:3.4.23.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
General information:
Sequence
0 MFLKNIFIAL AIALLVDATP TTTKRSAGFV ALDFSVVKTP KAFPVTNGQE GKTSKRQAVP
60 VTLHNEQVTY AADITVGSNN QKLNVIVDTG SSDLWVPDVN VDCQVTYSDQ TADFCKQKGT
120 YDPSGSSASQ DLNTPFKIGY GDGSSSQGTL YKDTVGFGGV SIKNQVLADV DSTSIDQGIL
180 GVGYKTNEAG GSYDNVPVTL KKQGVIAKNA YSLYLNSPDA ATGQIIFGGV DNAKYSGSLI
240 ALPVTSDREL RISLGSVEVS GKTINTDNVD VLLDSGTTIT YLQQDLADQI IKAFNGKLTQ
300 DSNGNSFYEV DCNLSGDVVF NFSKNAKISV PASEFAASLQ GDDGQPYDKC QLLFDVNDAN
360 ILGDNFLRSA YIVYDLDDNE ISLAQVKYTS ASSISALT
Download this sequence
in fasta formatDownload all sequences for 3.4.23.24
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
397751
Wright R.J.,Carne A.,Hieber A.D.,Lamont I.L.,Emerson G.W.,Sullivan P.A.
A second gene for a secreted aspartate proteinase in Candida albicans.
J. Bacteriol.
174
7848-7853
1992
397752
Mukai H.,Takeda O.,Asada K.,Kato I.,Murayama S.Y.,Yamaguchi H.
cDNA cloning of an aspartic proteinase secreted by Candida albicans.
Microbiol. Immunol.
36
1207-1216
1992
397753
White T.C.,Miyasaki S.H.,Agabian N.
Three distinct secreted aspartyl proteinases in Candida albicans.
J. Bacteriol.
175
6126-6133
1993
397754
Morrison C.J.,Hurst S.F.,Bragg S.L.,Kuykendall R.J.,Diaz H.,Pohl J.,Reiss E.
Heterogeneity of the purified extracellular aspartyl proteinase from Candida albicans: characterization with monoclonal antibodies and N-terminal amino acid sequence analysis.
Infect. Immun.
61
2030-2036
1993
397755
Magee B.B.,Hube B.,Wright R.J.,Sullivan P.J.,Magee P.T.
The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members.
Infect. Immun.
61
3240-3243
1993
397756
Smolenski G.,Sullivan P.A.,Cutfield S.M.,Cutfield J.F.
Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes.
Microbiology
143
349-356
1997
397757
De Bernardis F.,Arancia S.,Morelli L.,Hube B.,Sanglard D.,Schafer W.,Cassone A.
Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.
J. Infect. Dis.
179
201-208
1999
397758
Schaller M.,Januschke E.,Schackert C.,Woerle B.,Korting H.C.
Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo.
J. Med. Microbiol.
50
743-747
2001
397759
Farley P.C.,Christeller J.T.,Sullivan M.E.,Sullivan P.A.,Laing W.A.
Analysis of the interaction between the aspartic peptidase inhibitor SQAPI and aspartic peptidases using surface plasmon resonance.
J. Mol. Recognit.
15
135-144
2002
397760
Schaller M.,Bein M.,Korting H.C.,Baur S.,Hamm G.,Monod M.,Beinhauer S.,Hube B.
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.
Infect. Immun.
71
3227-3234
2003
397761
Schaller M.,Korting H.C.,Borelli C.,Hamm G.,Hube B.
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.
Infect. Immun.
73
2758-2765
2005
397762
Copping V.M.S.,Barelle C.J.,Hube B.,Gow N.A.R.,Brown A.J.P.,Odds F.C.
Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.
J. Antimicrob. Chemother.
55
645-654
2005
397763
Gropp K.,Schild L.,Schindler S.,Hube B.,Zipfel P.F.,Skerka C.
The yeast Candida albicans evades human complement attack by secretion of aspartic proteases.
Mol. Immunol.
47
465-475
2009
397764
Pietrella D.,Rachini A.,Pandey N.,Schild L.,Netea M.,Bistoni F.,Hube B.,Vecchiarelli A.
The inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity.
Infect. Immun.
78
4754-4762
2010
397765
Aoki W.,Kitahara N.,Miura N.,Morisaka H.,Yamamoto Y.,Kuroda K.,Ueda M.
Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans.
J. Biochem.
150
431-438
2011
397766
Ramage G.,Coco B.,Sherry L.,Bagg J.,Lappin D.F.
In vitro Candida albicans biofilm induced proteinase activity and SAP8 expression correlates with in vivo denture stomatitis severity.
Mycopathologia
174
11-19
2012
397767
Staniszewska M.,Bondaryk M.,Siennicka K.,Kurek A.,Orlowski J.,Schaller M.,Kurzatkowski W.
In vitro study of secreted aspartyl proteinases Sap1 to Sap3 and Sap4 to Sap6 expression in Candida albicans pleomorphic forms.
Pol. J. Microbiol.
61
247-256
2012
397768
Bochenska O.,Rapala-Kozik M.,Wolak N.,Bras G.,Kozik A.,Dubin A.,Aoki W.,Ueda M.,Mak P.
Secreted aspartic peptidases of Candida albicans liberate bactericidal hemocidins from human hemoglobin.
Peptides
48
49-58
2013
397769
Bochenska O.,Rapala-Kozik M.,Wolak N.,Aoki W.,Ueda M.,Kozik A.
The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5.
Acta Biochim. Pol.
63
403-410
2016
397770
Ikonomova S.P.,Moghaddam-Taaheri P.,Jabra-Rizk M.A.,Wang Y.,Karlsson A.J.
Engineering improved variants of the antifungal peptide histatin 5 with reduced susceptibility to Candida albicans secreted aspartic proteases and enhanced antimicrobial potency.
FEBS J.
285
146-159
2018
397771
Ikonomova S.P.,Moghaddam-Taaheri P.,Wang Y.,Doolin M.T.,Stroka K.M.,Hube B.,Karlsson A.J.
Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis.
Protein Sci.
29
480-493
2020
397772
Cutfield S.M.,Dodson E.J.,Anderson B.F.,Moody P.C.E.,Marshall C.J.,Sullivan P.A.,Cutfield J.F.
The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors.
Structure
3
1261-1271
1995
397773
Abad-Zapatero C.,Goldman R.,Muchmore S.W.,Hutchins C.,Stewart K.,Navaza J.,Payne C.D.,Ray T.L.
Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.
Protein Sci.
5
640-652
1996
