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Sequence of CATD_HUMAN

EC Number:3.4.23.5

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cathepsin D
P07339
Homo sapiens
412
44552
Reaction
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin

General information:

Sequence
show sequence in fasta format
  0 MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP
 60 AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH
120 HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG
180 EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ
240 PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL
300 MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ
360 AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
354779
Faust P.L.,Kornfeld S.,Chirgwin J.M.
Cloning and sequence analysis of cDNA for human cathepsin D.
Proc. Natl. Acad. Sci. U.S.A.
82
4910-4914
1985
354780
Westley B.R.,May F.E.B.
Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
Nucleic Acids Res.
15
3773-3786
1987
354781
Redecker B.,Heckendorf B.,Grosch H.W.,Mersmann G.,Hasilik A.
Molecular organization of the human cathepsin D gene.
DNA Cell Biol.
10
423-431
1991
354784
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
354785
May F.E.,Smith D.J.,Westley B.R.
The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point.
Gene
134
277-282
1993
354786
Augereau P.,Miralles F.,Cavailles V.,Gaudelet C.,Parker M.,Rochefort H.
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Mol. Endocrinol.
8
693-703
1994
354788
Kobayashi T.,Honke K.,Gasa S.,Fujii T.,Maguchi S.,Miyazaki T.,Makita A.
Proteolytic processing sites producing the mature form of human cathepsin D.
Int. J. Biochem.
24
1487-1491
1992
354789
Basrur V.,Yang F.,Kushimoto T.,Higashimoto Y.,Yasumoto K.,Valencia J.,Muller J.,Vieira W.D.,Watabe H.,Shabanowitz J.,Hearing V.J.,Hunt D.F.,Appella E.
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
J. Proteome Res.
2
69-79
2003
354790
Zhang H.,Li X.-J.,Martin D.B.,Aebersold R.
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
Nat. Biotechnol.
21
660-666
2003
354791
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
354792
Siintola E.,Partanen S.,Stromme P.,Haapanen A.,Haltia M.,Maehlen J.,Lehesjoki A.E.,Tyynela J.
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Brain
129
1438-1445
2006
354793
Chi A.,Valencia J.C.,Hu Z.-Z.,Watabe H.,Yamaguchi H.,Mangini N.J.,Huang H.,Canfield V.A.,Cheng K.C.,Yang F.,Abe R.,Yamagishi S.,Shabanowitz J.,Hearing V.J.,Wu C.,Appella E.,Hunt D.F.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
J. Proteome Res.
5
3135-3144
2006
354794
Lewandrowski U.,Moebius J.,Walter U.,Sickmann A.
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
Mol. Cell. Proteomics
5
226-233
2006
354795
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
354796
Didangelos A.,Yin X.,Mandal K.,Baumert M.,Jahangiri M.,Mayr M.
Proteomics characterization of extracellular space components in the human aorta.
Mol. Cell. Proteomics
9
2048-2062
2010
354797
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
354798
Halim A.,Ruetschi U.,Larson G.,Nilsson J.
LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
J. Proteome Res.
12
573-584
2013
354799
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
354800
Letronne F.,Laumet G.,Ayral A.M.,Chapuis J.,Demiautte F.,Laga M.,Vandenberghe M.E.,Malmanche N.,Leroux F.,Eysert F.,Sottejeau Y.,Chami L.,Flaig A.,Bauer C.,Dourlen P.,Lesaffre M.,Delay C.,Huot L.,Dumont J.,Werkmeister E.,Lafont F.,Mendes T.,Hansmannel F.,Dermaut B.,Deprez B.,Herard A.S.,Dhenain M.,Souedet N.,Pasquier F.,Tulasne D.,Berr C.,Hauw J.J.,Lemoine Y.,Amouyel P.,Mann D.,Deprez R.,Checler F.,Hot D.,Delzescaux T.,Gevaert K.,Lambert J.C.
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
EBioMedicine
9
278-292
2016
354801
Metcalf P.,Fusek M.
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.
EMBO J.
12
1293-1302
1993
354802
Baldwin E.T.,Bhat T.N.,Gulnik S.,Hosur M.V.,Sowder R.C. II,Cachau R.E.,Collins J.,Silva A.M.,Erickson J.W.
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc. Natl. Acad. Sci. U.S.A.
90
6796-6800
1993
354803
Papassotiropoulos A.,Bagli M.,Kurz A.,Kornhuber J.,Forstl H.,Maier W.,Pauls J.,Lautenschlager N.,Heun R.
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
Ann. Neurol.
47
399-403
2000
354804
Steinfeld R.,Reinhardt K.,Schreiber K.,Hillebrand M.,Kraetzner R.,Bruck W.,Saftig P.,Gartner J.
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Am. J. Hum. Genet.
78
988-998
2006
354805
Kousi M.,Lehesjoki A.E.,Mole S.E.
Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.
Hum. Mutat.
33
42-63
2012