Sequence of POLG_HRV14
EC Number:3.4.22.29
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
selective cleavage of Tyr-/-Gly bond in picornavirus polyprotein
General information:
Sequence
0 MGAQVSTQKS GSHENQNILT NGSNQTFTVI NYYKDAASTS SAGQSLSMDP SKFTEPVKDL
60 MLKGAPALNS PNVEACGYSD RVQQITLGNS TITTQEAANA VVCYAEWPEY LPDVDASDVN
120 KTSKPDTSVC RFYTLDSKTW TTGSKGWCWK LPDALKDMGV FGQNMFFHSL GRSGYTVHVQ
180 CNATKFHSGC LLVVVIPEHQ LASHEGGNVS VKYTFTHPGE RGIDLSSANE VGGPVKDVIY
240 NMNGTLLGNL LIFPHQFINL RTNNTATIVI PYINSVPIDS MTRHNNVSLM VIPIAPLTVP
300 TGATPSLPIT VTIAPMCTEF SGIRSKSIVP QGLPTTTLPG SGQFLTTDDR QSPSALPNYE
360 PTPRIHIPGK VHNLLEIIQV DTLIPMNNTH TKDEVNSYLI PLNANRQNEQ VFGTNLFIGD
420 GVFKTTLLGE IVQYYTHWSG SLRFSLMYTG PALSSAKLIL AYTPPGARGP QDRREAMLGT
480 HVVWDIGLQS TIVMTIPWTS GVQFRYTDPD TYTSAGFLSC WYQTSLILPP ETTGQVYLLS
540 FISACPDFKL RLMKDTQTIS QTVALTEGLG DELEEVIVEK TKQTVASISS GPKHTQKVPI
600 LTANETGATM PVLPSDSIET RTTYMHFNGS ETDVECFLGR AACVHVTEIQ NKDATGIDNH
660 REAKLFNDWK INLSSLVQLR KKLELFTYVR FDSEYTILAT ASQPDSANYS SNLVVQAMYV
720 PPGAPNPKEW DDYTWQSASN PSVFFKVGDT SRFSVPYVGL ASAYNCFYDG YSHDDAETQY
780 GITVLNHMGS MAFRIVNEHD EHKTLVKIRV YHRAKHVEAW IPRAPRALPY TSIGRTNYPK
840 NTEPVIKKRK GDIKSYGLGP RYGGIYTSNV KIMNYHLMTP EDHHNLIAPY PNRDLAIVST
900 GGHGAETIPH CNCTSGVYYS TYYRKYYPII CEKPTNIWIE GNPYYPSRFQ AGVMKGVGPA
960 EPGDCGGILR CIHGPIGLLT AGGSGYVCFA DIRQLECIAE EQGLSDYITG LGRAFGVGFT
1020 DQISTKVTEL QEVAKDFLTT KVLSKVVKMV SALVIICRNH DDLVTVTATL ALLGCDGSPW
1080 RFLKMYISKH FQVPYIERQA NDGWFRKFND ACNAAKGLEW IANKISKLIE WIKNKVLPQA
1140 KEKLEFCSKL KQLDILERQI TTMHISNPTQ EKREQLFNNV LWLEQMSQKF APLYAVESKR
1200 IRELKNKMVN YMQFKSKQRI EPVCVLIHGT PGSGKSLTTS IVGRAIAEHF NSAVYSLPPD
1260 PKHFDGYQQQ EVVIMDDLNQ NPDGQDISMF CQMVSSVDFL PPMASLDNKG MLFTSNFVLA
1320 STNSNTLSPP TILNPEALVR RFGFDLDICL HTTYTKNGKL NAGMSTKTCK DCHQPSNFKK
1380 CCPLVCGKAI SLVDRTTNIR YSVDQLVTAI ISDFKSKMQI TDSLETLFQG PVYKDLEIDV
1440 CNTPPPECIN DLLKSVDSEE IREYCKKKKW IIPEIPTNIE RAMNQASMII NTILMFVSTL
1500 GIVYVIYKLF AQTQGPYSGN PPHNKLKAPT LRPVVVQGPN TEFALSLLRK NIMTITTSKG
1560 EFTGLGIHDR VCVIPTHAQP GDDVLVNGQK IRVKDKYKLV DPENINLELT VLTLDRNEKF
1620 RDIRGFISED LEGVDATLVV HSNNFTNTIL EVGPVTMAGL INLSSTPTNR MIRYDYATKT
1680 GQCGGVLCAT GKIFGIHVGG NGRQGFSAQL KKQYFVEKQG QVIARHKVRE FNINPVNTPT
1740 KSKLHPSVFY DVFPGDKEPA VLSDNDPRLE VKLTESLFSK YKGNVNTEPT ENMLVAVDHY
1800 AGQLLSLDIP TSELTLKEAL YGVDGLEPID ITTSAGFPYV SLGIKKRDIL NKETQDTEKM
1860 KFYLDKYGID LPLVTYIKDE LRSVDKVRLG KSRLIEASSL NDSVNMRMKL GNLYKAFHQN
1920 PGVLTGSAVG CDPDVFWSVI PCLMDGHLMA FDYSNFDASL SPVWFVCLEK VLTKLGFAGS
1980 SLIQSICNTH HIFRDEIYVV EGGMPSGCSG TSIFNSMINN IIIRTLILDA YKGIDLDKLK
2040 ILAYGDDLIV SYPYELDPQV LATLGKNYGL TITPPDKSET FTKMTWENLT FLKRYFKPDQ
2100 QFPFLVHPVM PMKDIHESIR WTKDPKNTQD HVRSLCMLAW HSGEKEYNEF IQKIRTTDIG
2160 KCLILPEYSV LRRRWLDLF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
332878
Stanway G.,Hughes P.J.,Mountford R.C.,Minor P.D.,Almond J.W.
The complete nucleotide sequence of a common cold virus: human rhinovirus 14.
Nucleic Acids Res.
12
7859-7875
1984
332879
Lee W.M.,Monroe S.,Rueckert R.R.
Role of maturation cleavage in infectivity of picornaviruses: activation of an infectosome.
J. Virol.
67
2110-2122
1993
332880
Callahan P.L.,Mizutani S.,Colonno R.J.
Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14.
Proc. Natl. Acad. Sci. U.S.A.
82
732-736
1985
332881
Wessels E.,Duijsings D.,Lanke K.H.,van Dooren S.H.,Jackson C.L.,Melchers W.J.,van Kuppeveld F.J.
Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment.
J. Virol.
80
11852-11860
2006
332882
de Breyne S.,Bonderoff J.M.,Chumakov K.M.,Lloyd R.E.,Hellen C.U.
Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases.
Virology
378
118-122
2008
332884
Fuchs R.,Blaas D.
Productive entry pathways of human rhinoviruses.
Adv. Virol.
2012
826301-826301
2012
332885
Lyoo H.,van der Schaar H.M.,Dorobantu C.M.,Rabouw H.H.,Strating J.R.P.M.,van Kuppeveld F.J.M.
ACBD3 is an essential pan-enterovirus host factor that mediates the interaction between viral 3A protein and cellular protein PI4KB.
MBio
10
0-0
2019
332886
Robinson K.S.,Teo D.E.T.,Tan K.S.,Toh G.A.,Ong H.H.,Lim C.K.,Lay K.,Au B.V.,Lew T.S.,Chu J.J.H.,Chow V.T.K.,Wang Y.,Zhong F.L.,Reversade B.
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.
Science
0
0-0
2020
332887
Tsu B.V.,Beierschmitt C.,Ryan A.P.,Agarwal R.,Mitchell P.S.,Daugherty M.D.
Diverse viral proteases activate the NLRP1 inflammasome.
Elife
10
0-0
2021
332888
Rossman M.G.,Arnold E.,Erickson J.W.,Frankenberger E.A.,Griffith J.P.,Hecht H.-J.,Johnson J.E.,Kamer G.,Luo M.,Mosser A.G.,Rueckert R.R.,Sherry B.,Vriend G.
Structure of a human common cold virus and functional relationship to other picornaviruses.
Nature
317
145-153
1985
332889
Arnold E.,Rossman M.G.
The use of molecular-replacement phases for the refinement of the human rhinovirus 14 structure.
Acta Crystallogr. A
44
270-282
1988
332890
Arnold E.,Rossman M.G.
Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 A.
J. Mol. Biol.
211
763-801
1990
332891
Kolatkar P.R.,Bella J.,Olson N.H.,Bator C.M.,Baker T.S.,Rossmann M.G.
Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor.
EMBO J.
18
6249-6259
1999
332892
Gustin K.E.,Sarnow P.
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus.
J. Virol.
76
8787-8796
2002
332893
Dong Y.,Liu Y.,Jiang W.,Smith T.J.,Xu Z.,Rossmann M.G.
Antibody-induced uncoating of human rhinovirus B14.
Proc. Natl. Acad. Sci. U.S.A.
114
8017-8022
2017
332894
Horova V.,Lyoo H.,Rozycki B.,Chalupska D.,Smola M.,Humpolickova J.,Strating J.R.P.M.,van Kuppeveld F.J.M.,Boura E.,Klima M.
Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites.
PLoS Pathog.
15
E1007962-E1007962
2019
