EC Number   |
Protein Variants |
Reference |
|---|
   7.2.2.9 | C1375S |
the mutant exhibits trafficking behavior similar to that observed for the wild type enzyme |
718542 |
| 7.2.2.9 | C983A/C985A |
site-directed mutagenesis of CXC copper binding motif in the transmembrane copper site TM6, absence of alkali labile phosphoenzyme formation |
712378 |
| 7.2.2.9 | D1027A |
inactivating mutation of catalytic Asp1027, surface targeting |
685370 |
| 7.2.2.9 | D1027N |
site-directed mutagenesis of the P domain, absence of alkali labile phosphoenzyme formation |
712378 |
| 7.2.2.9 | D1230A |
retains 21% of the activity compared to wild type |
654428 |
| 7.2.2.9 | D1267V |
naturally occuring mutation in the ATP-binding loop of ATP7B, deleterious mutation, unable to grow under iron limitation |
712129 |
| 7.2.2.9 | D40A |
site-directed mutagenesis, inactive mutant |
695478 |
| 7.2.2.9 | D598A |
inactive |
719971 |
| 7.2.2.9 | DD1219/1220AA |
retains 80% of the activity compared to wild type |
654428 |
| 7.2.2.9 | delM1-M54 |
a truncated CopB lacking the first 54 amino acids is constructed to characterize the N-terminal metal binding domain. This enzyme shows reduced ATPase activity (50% of wild type) but no changes in metal selectivity, ATP dependence, or phosphorylation levels |
719816 |
