EC Number |
Protein Variants |
Reference |
---|
6.3.3.2 | D124A |
inactive |
728751 |
6.3.3.2 | D151A |
the mutant shows increased turnover number compared to the wild type enzyme |
728751 |
6.3.3.2 | D154A |
inactive |
728751 |
6.3.3.2 | D154A |
site-directed mutagenesis, the mutant shows 0.9% of the wild-type catalytic activity |
703027 |
6.3.3.2 | D81A |
the mutant shows reduced turnover number compared to the wild type enzyme |
728751 |
6.3.3.2 | E225Stop |
mutation identified in a patient suffering MTHFD1 deficiency |
745499 |
6.3.3.2 | E61A |
site-directed mutagenesis, the mutant shows 8.6% of the wild-type catalytic activity |
703027 |
6.3.3.2 | F55A |
site-directed mutagenesis, the mutant shows 53.6% of the wild-type catalytic activity |
703027 |
6.3.3.2 | F85A |
site-directed mutagenesis, the mutant shows 72.3% of the wild-type catalytic activity |
703027 |
6.3.3.2 | K10A |
site-directed mutagenesis, the mutant shows 7.5% of the wild-type catalytic activity |
703027 |