EC Number |
Protein Variants |
Reference |
---|
6.3.2.5 | A275T |
temperature sensitive mutant dfp-1 |
648958 |
6.3.2.5 | A275V |
unable to form dimers |
648961 |
6.3.2.5 | D203N |
unable to form dimers |
648961 |
6.3.2.5 | K289Q |
complete loss of enzymic activity |
648961 |
6.3.2.5 | K310Q |
the mutant has very low activity |
-, 674749 |
6.3.2.5 | K310Q |
very low activity |
-, 674749 |
6.3.2.5 | more |
mutation in dPPCS impair female fecundity and fertility, and disrupts the organization of the somatic and germ line cells, affects F-actin organization and results in abnormal PtdIns(4,5)P2 localization. Improper cell organization coincides with aberrant localization of the membrane molecules Gurken (Grk) and Notch, whose activities are required for specification of the follicle cells that pattern the eggshell. Mutations in dPPCS also induce alterations in scutellar patterning and cause wing vein abnormalities, phenotype, detailed overview |
691514 |
6.3.2.5 | N210D |
complete loss of enzymic activity, but intermediate 4-phosphopanthotenoyl-CMP is formed |
648961 |
6.3.2.5 | N210H |
used for isolation of reaction intermediate |
648958 |
6.3.2.5 | N210K |
used for isolation of reaction intermediate |
648958 |