EC Number |
Protein Variants |
Reference |
---|
4.3.2.1 | A398D |
no activity, 15.55 of wild-type activity if coexpressed with Q286R |
650043 |
4.3.2.1 | A41G/I43M |
mutant without enzyme activity |
664119 |
4.3.2.1 | C441A |
striking decrease in the enzymatic activity, while retaining the overall secondary to quaternary structure of the protein |
-, 747996 |
4.3.2.1 | C441S |
significant increase in activity, as compared to the wild-type enzyme, the mutant enzyme has higher thermal stability and maintains significant activity at high temperatures. The mutant shows a marked increase in enzymatic activity as it lacks this cysteine dependent feedback inhibition |
-, 747996 |
4.3.2.1 | D115A |
mutant with 45% enzyme activity |
664119 |
4.3.2.1 | D115E |
mutant with 42.6% enzyme activity |
664119 |
4.3.2.1 | D31N |
missense mutation found in patients with late onset of argininosuccinic aciduria, residual activity |
709062 |
4.3.2.1 | D87G |
no activity, 35.2% of wild-type activity if coexpressed with Q286R |
650043 |
4.3.2.1 | E115D |
mutant without enzyme activity |
664119 |
4.3.2.1 | E189G |
the mutant enzyme decreased enzyme efficiency (78% of wild-type), no significant decrease in Km-value, displays thermal instability |
748357 |