    4.2.1.157 | more |
mutation or deletion of hadC, phenotype, overview. The hadC allele of that Mycobacterium tuberculosis strain H37Ra contains the previously reported single nucleotide insertion (C) in a GC rich region at base pair 88 (Rv0637 numbering), that it causes a frameshift in MRA0648, generating an early stop codon. The deletion mutant is termed H37RaDELTAhadC. No complementation is observed after transformation of Mycobacterium tuberculosis H37RvDELTAhadC mutant with hadC allele from Mycobacterium tuberculosis H37Ra (hadCRa), and the complete deletion of this allele in H37Ra does not significantly affect the mycolic distribution. Complementation of Mycobacterium tuberculosis strain H37Ra with either the wild-type hadC (hadCRv) or both wild-type hadB and hadC allele(s) (hadBCRv) from Mycobacterium tuberculosis strain H37Rv results in similar intermediate phenotypes |
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