EC Number   |
Protein Variants |
Reference |
|---|
    4.2.1.109 | D72A |
site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme |
730835 |
| 4.2.1.109 | D72A/K90A |
site-directed mutagenesis, the mutant shows a similar level of pyroptosis inhibition as the wild-type enzyme, but a significant loss of apoptosis inhibition activity |
730835 |
| 4.2.1.109 | K90A |
site-directed mutagenesis, the mutant shows a similar level of pyroptosis inhibition as the wild-type enzyme, but a significant loss of apoptosis inhibition activity |
730835 |
| 4.2.1.109 | more |
transient silencing of the enzyme in HeLa cells. Stable knockdown of the enzyme specifically affects growth in 5-methylthioadenosine and depletes intracellular levels of methionine |
728588 |
| 4.2.1.109 | P185A |
site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme |
730835 |
| 4.2.1.109 | Y184A |
site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme |
730835 |
| 4.2.1.109 | Y184A/P185A |
site-directed mutagenesis, the mutant shows similar levels of pyroptosis inhibition and apoptosis inhibition as the wild-type enzyme |
730835 |
