EC Number   |
Protein Variants |
Reference |
|---|
    4.1.2.4 | C47A |
the mutant enzyme is highly sensitive to crotonaldehyde and acetaldehyde |
-, 748275 |
| 4.1.2.4 | C47G |
the mutant enzyme is highly sensitive to crotonaldehyde and acetaldehyde |
-, 748275 |
| 4.1.2.4 | C47L |
the mutant enzyme shows no loss in stereoselectivity, the mutant is fully resistant to inhibition by crotonaldehyde |
-, 748275 |
| 4.1.2.4 | C47M |
the mutant is both, the most acetaldehyde resistant variant and well performing on stereoselectivity, it is less resistant to crotonaldehyde than mutant C47M |
-, 748275 |
| 4.1.2.4 | C47S |
although serine is similar to cysteine, this variant is ten times more stable against acetaldehyde than the wildtype |
-, 748275 |
| 4.1.2.4 | D84G/DELTAY259 |
the catalytic activity towards 2-deoxy-D-ribose-5-phosphate cleavage is increased 4fold compared to the wild type enzyme |
678858 |
| 4.1.2.4 | down |
cells in which deoxyribose-phosphate aldolase expression is down-regulated using short hairpin RNA form fewer stress granules and are more prone to apoptosis after clotrimazole stress, suggesting the importance of deoxyribose-phosphate aldolase for stress granule formation |
747165 |
| 4.1.2.4 | F165I |
mutant enzyme shows 87.5 % of the activity of wild-type enzyme, preferable substrate tolerance compared with wild-type enzyme KDERA when the reactions are performed with 200 mM D-glyceraldehyde and acetaldehyde |
746897 |
| 4.1.2.4 | F200I |
2.4fold improvement in enzyme activities compared to wild-type enzyme, preferable substrate tolerance compared with wild-type enzyme KDERA when the reactions are performed with 200 mM D-glyceraldehyde and acetaldehyde |
746897 |
| 4.1.2.4 | F200I |
shows a nearly 14fold increase in productivity for (3R,5S)-6-chloro-2,4,6-trideoxyhexapyranoside formation |
678858 |
