4.1.1.35 | more |
by using Tn5 transposon mutagenesis, a gene, PpmrI, is identified which plays important roles in controlling lipopolysaccharides modification, polymyxin B susceptibility, biofilm formation, and cell invasion in Proteus mirabilis. The expression of PpmrI can be induced by polymyxin B via RppA, a response regulator of the bacterial two-component system. Together, these results reveal a mechanism by which Proteus mirabilis regulates polymyxin B resistance and virulence |
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