EC Number   |
Protein Variants |
Reference |
|---|
    4.1.1.12 | D360P |
site-directed mutagenesis, the mutant shows similar 4-decarboxylation activity but reduced aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | E84K/E88K |
the mutant retains 13% activity compared to the wild type enzyme |
706788 |
| 4.1.1.12 | F204W |
site-directed mutagenesis, the mutant shows slightly reduced 4-decarboxylation activity but highly increased aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | H123Y |
site-directed mutagenesis, the mutant shows reduced 4-decarboxylation activity and slightly increased aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | H337R |
site-directed mutagenesis, the mutant shows reduced 4-decarboxylation activity but similar aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | K17A |
the mutant shows 131.2% activity compared to the wild type enzyme |
-, 706788 |
| 4.1.1.12 | K315A |
the mutant shows 36.7% activity compared to the wild type enzyme |
-, 706788 |
| 4.1.1.12 | K347R |
site-directed mutagenesis, the mutant shows similar 4-decarboxylation activity but reduced aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | M178L |
site-directed mutagenesis, the mutant shows reduced 4-decarboxylation activity but unaltered aminotransferase compared to the wild-type enzyme |
671797 |
| 4.1.1.12 | P257H |
the mutation results in inactivation of the enzyme, but does not affect the overall structure (0.08% of the wild type enzymatic activity) |
690741 |
