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EC Number
Protein Variants
Commentary
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3.5.4.37
E861A
editing-deficient knock-in mutation. Adar1(E861A/E861A) embryos die at embryonic day 13.5, with activated interferon and double-stranded RNA-sensing pathways
758462
3.5.4.37
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exchange of deaminase domains between ADAR1 and ADAR2 shows that this domain plays a dominant role in defining the substrate specificity of the resulting enzyme
721045
3.5.4.37
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mutations for ADAR1 and ADAR2 within the double-stranded RNA binding domains, that result in the total loss of all binding for long and short dsRNA. These dsRNA binding-deficient ADARs nevertheless dimerize identically to their wild type counterparts, revealing that ADAR dimerization is not mediated by dsRNA. Two monomers with functional double-stranded RNA binding domains are required by a dimer for dsRNA binding and A to I editing activities
719839
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