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Results 1 - 3 of 3
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.37E861A editing-deficient knock-in mutation. Adar1(E861A/E861A) embryos die at embryonic day 13.5, with activated interferon and double-stranded RNA-sensing pathways 758462
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.37more exchange of deaminase domains between ADAR1 and ADAR2 shows that this domain plays a dominant role in defining the substrate specificity of the resulting enzyme 721045
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.37more mutations for ADAR1 and ADAR2 within the double-stranded RNA binding domains, that result in the total loss of all binding for long and short dsRNA. These dsRNA binding-deficient ADARs nevertheless dimerize identically to their wild type counterparts, revealing that ADAR dimerization is not mediated by dsRNA. Two monomers with functional double-stranded RNA binding domains are required by a dimer for dsRNA binding and A to I editing activities 719839
Results 1 - 3 of 3