EC Number |
Protein Variants |
Reference |
---|
3.5.4.10 | C61A |
site-directed mutagenesis, the mutant shows 8fold increased activity compared to the wild-type enzyme |
685152 |
3.5.4.10 | C807T |
naturally occuring polymorphism involved in gastric cancer development |
719305 |
3.5.4.10 | D125A |
10fold increase in KM-value |
658026 |
3.5.4.10 | D125A |
dramatically reduced kcat-value |
485758 |
3.5.4.10 | D125E |
5fold increase in Km-value |
658026 |
3.5.4.10 | D125E |
dramatically reduced kcat-value |
485758 |
3.5.4.10 | D125N |
3fold increase in Km-value |
658026 |
3.5.4.10 | D125N |
dramatically reduced kcat-value |
485758 |
3.5.4.10 | E102Q |
site-directed mutagenesis, inactive mutant |
685152 |
3.5.4.10 | H256A |
complete loss of activity, mutation lowers the thermostability |
756701 |