EC Number |
Protein Variants |
Reference |
---|
3.4.24.34 | E198A |
catalytically inactive |
734213 |
3.4.24.34 | E198A |
mutant enzyme is not activated by 4-aminophenylmercuric acetate, no collagen cleavage activity |
669348 |
3.4.24.34 | more |
construction of MMP-8 knockout mice by gene targeting, MMP-8-deficient female mice develop tongue squamous cell carcinoma at a significantly higher incidence than wild-type mice exposed to carcinogen 4-nitroquinoline-N-oxide, overview |
683311 |
3.4.24.34 | more |
construction of MMP8-null mice, phenotype of I/R injury mice and non-ischemic mice. Genetic ablation of MMP8 preserves claudin-3 expression |
-, 753531 |
3.4.24.34 | more |
enzyme silencing by MMP8-specific shRNA |
754776 |
3.4.24.34 | more |
generation of MMP-8 knockout mutant mice. In contrast to septic adult mice, genetic ablation of MMP8 increases mortality following bacterial peritonitis in juvenile mice. This increase in mortality is associated with rexadduced bacterial clearance and reduced NET efficiency. Juvenile MMP8 null mice have greater mortality and higher bacterial burden than wild-type mice. Genetic ablation of MMP8 in juvenile mice increases mortality following sepsis from polymicrobial peritonitis |
-, 754754 |
3.4.24.34 | more |
genotyping and identification of the MMP8 single nucleotide polymorphism rs11225395, located 0.8 kB 5' of the transcription start site |
710178 |
3.4.24.34 | more |
MMP8-/- mice, of a mixed C57BL/6J/129 background, deficient in collagenase-2/MMP-8 are more susceptible to develop skin cancer compared to wild-type mice, mutant mice show a significant delay in wound closure and an altered inflammatory response in their wounds, with a delay of neutrophil infiltration during the first days and a persistent inflammation at later time points, alterations in the TGF-beta1 signaling pathway and by an apoptosis defect in MMP8-/- mice, phenotype, overview |
-, 683454 |
3.4.24.34 | more |
polymorphonuclear cell infiltration towards lipopolysaccharides is abrogated in MMP-8-null mice |
683989 |
3.4.24.34 | more |
topical dexamethasone (Dex)-treated MMP-8 knockout mice in the corneal alkali burn murine model show reduced corneal clarity, increased expression of inflammatory mediators (IL-6, CXCL1, and MMP-1 mRNA) and increased neutrophil infiltration at 2D and 5D compared to Dex-treated wild-type mice. The accumulation of neutrophils is reduced in wounded corneas of MMP-8 knockout mice subjected to the corneal alkali burn murine (CM) model |
-, 754245 |