EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.17 | E219A |
NMR studies used MMP-12 preserved by E219A substitution of the general base |
717387 |
| 3.4.24.17 | E219A |
site-directed mutagenesis, catalytically inactive mutant |
733275 |
| 3.4.24.17 | more |
catalytic domain (residues 83-247) are used in this study |
717280 |
| 3.4.24.17 | more |
enzyme overexpression im lymphoma transfectants significantly improves their ability to migrate through the matrix. Animals injected with lymphoma cells expressing enzyme constitutively develop thymic lymphoma more rapidly than those injected with control cells. Local expression of enzyme promotes lymphoma progression |
667382 |
| 3.4.24.17 | more |
enzyme silencing by siRNA in RAW264.7 cells |
735131 |
| 3.4.24.17 | more |
generation of enzyme knockout mutants |
-, 733946 |
| 3.4.24.17 | more |
generation of specific recombinant human monoclonal antibody SP3, which is specific to the murine MMP-3 catalytic domain |
-, 708420 |
| 3.4.24.17 | more |
Less disruption of blood-brain barrier after intracerebral lipopolysaccharide injection in enzyme knockout animals than in wild-type. Mutant animals show lower level of matrix metalloproteinase MMP-9 but similar levels of activation as wild-type |
670386 |
| 3.4.24.17 | more |
MMP-3 deficient mice are crossed back to a homozygous BL10 background for 10 generations as described above. Male MMP-3 knock-out and BL10 wild-type mice are used for the experimental setting |
-, 755661 |
| 3.4.24.17 | more |
MMP-3-/- mice kept on high fat diet show adipocyte hypertrophy in adipose tissues |
707379 |
