EC Number |
Protein Variants |
Reference |
---|
3.4.21.27 | C147S |
inactive |
754516 |
3.4.21.27 | C321S |
the mutant shows wild type activity |
754516 |
3.4.21.27 | C362S/C482S |
site-directed mutagenesis |
683682 |
3.4.21.27 | C362S/C482S |
site-directed mutagenesis, the mutant shows increased platelet binding compared to the wild-type enzyme |
683160 |
3.4.21.27 | C398Y |
exhibits a dominant negative effect when coexpressed with wild-type FXI and is associated with FXI deficiency that may be inherited in a dominant manner |
707856 |
3.4.21.27 | C482S |
the mutant shows 1.45fold enhanced activity as compared with the wild type enzyme |
754516 |
3.4.21.27 | C500S |
inactive |
731076 |
3.4.21.27 | E98A |
the mutant has normal Km and kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis, and is inhibited by protease nexin 2 with normal value of Ki |
717844 |
3.4.21.27 | E98D |
the mutant has normal Km and decreased kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis |
717844 |
3.4.21.27 | E98V |
the mutant has increased Km and decreased kcat values for L-pyroGlu-L-Pro-L-Arg-4-nitroanilide hydrolysis, the mutant has deficient kcat values for factor IX hydrolysis |
717844 |