EC Number |
Protein Variants |
Reference |
---|
3.2.2.23 | A288V |
naturally occuring polymorphism, the mutant displays opposite-base specificity similar to that of wild-type OGG1, activity, substrate specificity and kinetics compared to the wild-type enzyme, overview |
708484 |
3.2.2.23 | D322N |
naturally occuring polymorphism, the mutant is 2.3fold more specific for the correct opposite base than the wild-type enzyme, activity, substrate specificity and kinetics compared to the wild-type enzyme |
708484 |
3.2.2.23 | E131R |
loss of activity |
750392 |
3.2.2.23 | E173Q |
no enzymic activity, E173 may play a crucial role in forming the active site pocket |
667594 |
3.2.2.23 | E2Q |
no enzymic activity, interactions with G167 and Y170 are interupted |
667594 |
3.2.2.23 | E3Q |
crystallization data |
680361 |
3.2.2.23 | E3Q |
inactive. Mutant binds DNA duplexes containing spiroiminodihydantoin or guanidinohydantoin about 1000fold more tightly over corresponding duplexes containing 8-oxoguanine |
678318 |
3.2.2.23 | E77S |
in wild-type, 8-oxoguanine is bound via E77 in syn conformation. In mutant E77S, which reflects the sequence of the Escherichia coli enzyme, 8-oxoguanine is preferentially bound in the anti conformation |
678139 |
3.2.2.23 | F110A |
the mutation affects the enzyme activity, especially in the case of oxoG/C substrate, in the second and third reaction steps |
710030 |
3.2.2.23 | F110W |
the mutation affects the enzyme activity, especially in the case of oxoG/C substrate, in the second and third reaction steps |
710030 |