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Results 1 - 10 of 11 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130C188A enzymatic activity can not be fully rescued with a back-engineered Cys188Ala CHO cell endomannosidase 679134
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130C188S enzymatic activity can not be fully rescued with a back-engineered Cys188Ser CHO cell endomannosidase 679134
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130C188W enzyme activity can be reversed in cells with a back-engineered Cys188Trp CHO cell endomannosidase, in particular N-glycans of alpha1-antitrypsin become fully processed 679134
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130E154A the mutant shows near zero activity -, 732816
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130E329A the mutant shows near zero activity -, 732816
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130E332A the mutant shows approximate 50fold decrease in catalytic activity with respect to wild type enzyme -, 732816
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130E333Q inactive 731659
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130E407D the mutant has excellent transglycosylation activity and extremely low hydrolytic activity. The minimum motif required for glycosyl acceptor is Man-alpha-(1->2)-Man 750314
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130more in CHO-K1 cells expressing DELTAsig-rEndo, lacking the whole signal sequence, or DELTATMD-rEndo, lacking the transmembrane domain, endomannosidase is undetectable. DELTACT-rEndo, lacking the cytoplasmic tail, exhibits an ER localization and fails to maintain a type II membrane topology 697210
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.130W188C molecular defect in CHO cells, is functionally important since it alone results in endoplasmic reticulum mislocalization of endomannosidase and causes greatly reduced in vivo activity 679134
Results 1 - 10 of 11 > >>