EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.16 | C246S |
no dephosphorylation of SAPK |
655987 |
| 3.1.3.16 | C291R |
site-directed mutagenesis, mutation of a hydrophobic surface pocket residue of subunit PP1alpha, the mutant shows reduced activity and impaired binding to protein phosphatase inhibitor-1 and protein phosphatase inhibitor-2, as well as to the neuronal regulatory subunit neurabin-I, and GM, the skeletal muscle glycogen-targeting subunit |
665615 |
| 3.1.3.16 | C3S |
reduced membrane association |
656009 |
| 3.1.3.16 | C8A |
site-directed mutagenesis, inactive enzyme mutant of SP-PTP |
751599 |
| 3.1.3.16 | C93S |
site-directed mutagenesis, inactive mutant |
751975 |
| 3.1.3.16 | C95S |
loss in activity |
-, 656084 |
| 3.1.3.16 | D122A |
site-directed mutagenesis, catalytically inactive mutant |
-, 751129 |
| 3.1.3.16 | D136Y |
the mutant shows decreased catalytic efficiency compared to the wild type enzyme |
-, 730314 |
| 3.1.3.16 | D18Y |
inactive |
-, 730314 |
| 3.1.3.16 | D192A |
site-directed mutagenesis, the mutant has abolished PhpP activity in vitro |
-, 750204 |
