EC Number   |
Protein Variants |
Reference |
|---|
   3.1.22.1 | A335Term |
does not eliminate DNase II activity |
708175 |
| 3.1.22.1 | A58del |
in Japanese, African, Korean and Caucasian subjects, homozygous for the G292 allele. Shows almost no DNase II activity |
708175 |
| 3.1.22.1 | AP10T |
point mutation in the hinge region of LEI, has decreased anti-protease activity. Cells overexpressing wild-type LEI or AP10T-LEI have the same survival rate under unstressed condition. Mutant retains its pro-apoptotic activity when transformed into L-DNase II by an apoptotic stimulus (e.g., hexa-methylene-amiloride treatment). When mutant cells are treated with etoposide they do not present the same survival rate than wild-type cells |
696403 |
| 3.1.22.1 | C11A |
the mutation decreases the activity |
649749 |
| 3.1.22.1 | C159A |
complete loss of activity |
649749 |
| 3.1.22.1 | C19A |
complete loss of activity |
649749 |
| 3.1.22.1 | C267A |
complete loss of activity |
649749 |
| 3.1.22.1 | C299A |
the mutation increases the activity |
649749 |
| 3.1.22.1 | C308A |
complete loss of activity |
649749 |
| 3.1.22.1 | C327A |
complete loss of activity |
649749 |
