EC Number   |
Protein Variants |
Reference |
|---|
   3.1.1.106 | C199A |
the mutant shows about 90.4% of wild type activity |
751029 |
| 3.1.1.106 | D122A |
the mutant shows about 24.5% of wild type activity |
751029 |
| 3.1.1.106 | D160A |
the mutant shows about 57% of wild type activity |
751029 |
| 3.1.1.106 | D167A |
the mutant shows about 68.7% of wild type activity |
751029 |
| 3.1.1.106 | D184A |
the mutant shows about 39.3% of wild type activity |
751029 |
| 3.1.1.106 | D35A |
the mutant shows strongly reduced activity compared to the wild type enzyme |
751419 |
| 3.1.1.106 | D77N/D78N |
hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations |
752026 |
| 3.1.1.106 | E238Q/E239Q |
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose |
752026 |
| 3.1.1.106 | E261Q/E262Q |
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose |
752026 |
| 3.1.1.106 | G100E |
the mutant isoform MacroD2 lacks hydrolase and ADP-ribose-binding activities |
751688 |
