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Results 1 - 10 of 45 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5A215V the mutation is associated with succinyl-CoA:3-ketoacid CoA transferase deficiency 738807
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5A215V the mutation is associated with succinyl-CoA:3-ketoacid CoA transferase deficiency and retains 3.5% residual activity 724424
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C129S like wild-type SCOT rapid modification in the presence of acyl-CoA substrates 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C196S site-directed mutagenesis, the mutant protein is modified rapidly in the presence of acyl-CoA substrates in analogy to the wild-type enzyme 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C196S specific activity similar to wild-type SCOT 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C28A specific activity similar to C28S mutant 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C28S site-directed mutagenesis, the mutant protein is modified much more slowly than the wild-type enzyme, indicating that Cys28 is the residue exposed on binding CoA, the specific activity of the C28S mutant protein is unexpectedly lower than that of wild-type SCOT 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C28S slow modification in the presence of acyl-CoA substrates, a chloride ion is bound to one of four active sites in the crystal structure of the C28S mutant protein, mimicking substrate, interacting with Lys329, Asn51, and Asn52 672216
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C456F missense mutation derived from a SCOT-deficient patient, no enzyme activity 645992
Show all pathways known for 2.8.3.5Display the word mapDisplay the reaction diagram Show all sequences 2.8.3.5C456F no activity 663018
Results 1 - 10 of 45 > >>