EC Number   |
Protein Variants |
Reference |
|---|
   2.7.1.166 | A112V |
spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation results in low level of enzymic acitivity |
722384 |
| 2.7.1.166 | D193N |
spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation leads to complete loss of enzymic acitivity |
722384 |
| 2.7.1.166 | H168Y |
spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Residue is critical for Kdo kinase function and therefore glycoform A lipopolysaccharide assembly |
722384 |
| 2.7.1.166 | R123P |
spontaneous KdkA mutant strain isolated from birds inoculated with high doses of a heptosyltransferase hptA mutant. The birds developed fowl cholera and the Pasteurella multocida isolates recovered from diseased birds no longer express truncated lipopolysaccharide. Mutation is likely to have a significant impact on the secondary structure and probably affects the hinge action of the linker region |
722384 |
