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Results 1 - 9 of 9
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EC Number Protein Variants Commentary Reference
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108G405S naturally occuring mutation, identified in the isolated mutant strain MD2/1-9, the mutation leads to reduced dolichol kinase activity and the enhanced secretion phenotype -, 761104
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108G405S/I419S site-directed mutagenesis, despite some glycosylation defects, double DK mutations (G405S and I419S) in the Kluyveromyces lactis mutant strain demonstrate three times the level of recombinant alpha-amylase secretion compared to wild-type strain. Overexpression of potential suppressors KlMNN10, KlSEL1, KlERG20, KlSRT1, KlRER2, KlCAX4, KlLPP1 and KlDPP1 in the DK-mutant strain restores carboxypeptidase Y glycosylation to different extents and, with the exception of KISRT1, reduces alpha-amylase secretion to levels observed in wild-type cells -, 761104
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108G471D site-directed mutagenesis,inactive mutant 761619
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108I419S naturally occuring mutation, identified in the isolated mutant strain MD2/1-9, the mutation leads to reduced dolichol kinase activity and the enhanced secretion phenotype -, 761104
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108more construction of two independent lines of T-DNA-tagged AtDOK1 mutants, designated dok1-1 (CS822420; SAIL_529_E06) and dok1-2 (CS856101; WiscDsLox443D6), with T-DNA insertions in exons 8 and 13, respectively. Mutant dok1-1/+ and wild-type seed morphologies show no significant differences, and dok1-1/+ and the wild type did not differ in seed germination rates 739314
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108more creation of leaky knockdown mutants of gene DOK1 by microRNA-mediated gene suppression technique. Knockout of gene DOK1 causes lethality, while the DOK1 knockdown mutants show an early flowering phenotype without any remarkable growth defect in vegetative tissues 761619
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108more phenotypic characterization of CBS2359-KlSEC59 mutants, overview -, 761104
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108Q483K naturally occuring homozygous c.1447C>A DOLK mutation involved in enzyme deficiency and a phenotype with anatomic malformations and multi-systemic dysfunction 739079
Show all pathways known for 2.7.1.108Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.108W332G mutated Sec59-1p bears the single amino acid substitution Trp(332) to Gly, region predicted to be responsible for the substrate (dolichol) binding -, 677274
Results 1 - 9 of 9
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