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EC Number	Protein Variants	Commentary	Reference
2.6.1.9	K214A	increased pKa	637153
2.6.1.9	N157A	increased pKa	637153
2.6.1.9	N157A/R335L	increased pKa	637153
2.6.1.9	N99D	6fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate	684151
2.6.1.9	R335L	increased pKa	637153
2.6.1.9	Y123F	4fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate	684151
2.6.1.9	Y127F	about 20% of wild-type activity with L-histidinol phosphate, no significant loss of activity with phenylalanine	-, 739670
2.6.1.9	Y21F	10fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate	684151
2.6.1.9	Y257F	5fold reduction in ratio kcat to Km for substrates L-histidinol phosphate, 2-oxoglutarate	684151

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Release 2023.1 (January 2023)