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Results 1 - 10 of 10
EC Number Protein Variants Commentary Reference
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79A168G site-directed mutagenesis, altered substrate binding kinetics compared to wild-type 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79E108K site-directed mutagenesis, altered substrate binding kinetics compared to wild-type 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79K12G naturally occuring mutant, the incompetent PATs of Rhizobium meliloti (UniProt ID P58350) has a G instead of K12 and shows reduced PAT activity at prephenate concentrations up to 2.5 mM using a coupled assay method. The mutant shows reduced activity and altered kinetics compared to the wild-type 759178
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79K169S site-directed mutagenesis, inactive with aspartate and glutamate 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79K169V site-directed mutagenesis, inactive with glutamate, altered substrate binding kinetics compared to wild-type 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79K306A site-directed mutagenesis, structure comparison with wild-type, overview. The alanine substitution of Lys306 prevents Schiff base formation with the cofactor, inactive mutant 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79more site-directed mutagenesis, modeling, and molecular dynamics simulations reveal that K/R/Q12 residue (numbering according to Thermus thermophilus 1beta AAT) is a signature of the PAT function of 1beta AAT. It is present in the N-terminal flexible loop only in PAT competent 1beta-AAT and has a possible role in stabilizing prephenate by interacting with its 4-hydroxy group 759178
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79R445G site-directed mutagenesis, inactive mutant 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79T84V site-directed mutagenesis, altered substrate binding kinetics compared to wild-type 759965
Show all pathways known for 2.6.1.79Display the reaction diagram Show all sequences 2.6.1.79T84V/K169V site-directed mutagenesis, altered substrate binding kinetics compared to wild-type 759965
Results 1 - 10 of 10