EC Number |
Protein Variants |
Reference |
---|
2.6.1.13 | C154S |
mutant shows drastically reduced activity. Activity can be activated by Trx but not to the same extent as wild-type |
722970 |
2.6.1.13 | C154S/C163S |
double mutant shows the same phenotype as mutant C154S |
722970 |
2.6.1.13 | C163S |
mutant degrades ornithine with the same specific activity as the wild-type, and the Trx-mediated activation occurres at higher Trx concentrations when compared to OAT wild-type |
722970 |
2.6.1.13 | C316S |
transamination of ornithine and 2-oxoglutarate with an activity is reduced to 25-35% of the wild-type. Mutants can be activated by Trx and reaches a specific activity comparable to PfOAT wild-type with Trx |
722970 |
2.6.1.13 | C350S |
transamination of ornithine and 2-oxoglutarate with an activity is reduced to 25-35% of the wild-type. Mutants can be activated by Trx and reaches a specific activity comparable to PfOAT wild-type with Trx |
722970 |
2.6.1.13 | C390S |
transamination of ornithine and 2-oxoglutarate with an activity is reduced to 25-35% of the wild-type. Mutants can be activated by Trx and reaches a specific activity comparable to PfOAT wild-type with Trx |
722970 |
2.6.1.13 | E235A |
mutant retains its regiospecificity for the gamma-amino group of ornithine, but the glutamate reaction is enhanced 650fold, whereas only a 5fold enhancement of the ketoglutarate reaction rate results |
674489 |
2.6.1.13 | E235S |
mutation leads to a lowering of the apparent rate and an increase of the dissociation constant |
674489 |
2.6.1.13 | G237D |
patient with gyrate atrophy of the choroid and retina, mutation of both alleles, no enzymic activity in white blood cells. Son of patient is heterozygous for the mutation and has 45% of normal values for enzyme activity |
663430 |
2.6.1.13 | L402P |
mutation based on mutant identified in humans, abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype |
738432 |